Latent Space: The AI Engineer Podcast Transcripts
Latent.Space · 228 episodes with transcripts
The podcast by and for AI Engineers! In 2025, over 10 million readers and listeners came to Latent Space to hear about news, papers and interviews in Software 3.0.
Spoken has transcripts of 228 Latent Space: The AI Engineer Podcast episodes, with the speakers named. The newest listed here is from October 14, 2026.
Every Latent Space: The AI Engineer Podcast transcript in one script
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Latest Latent Space: The AI Engineer Podcast transcripts
Lab-in-the-Loop at Compute Speed — Ian Quigley, Leash Bio
October 14, 2026
Ian Quigley (0:00)
My co-founder Andrew Blevins and I were at Procursion looking at a small molecule on a screen. And then a medicinal chemist walked by, it's the skin of Mike Cucarisi, and Mike was like, hey, looks like a Stuart Tribert molecule. And then we were like, oh no, you can tell just by walking by? You like who made this?…
Brandon Anderson (0:26)
Well, they did learn something.
Ian Quigley (0:29)
They don't learn physics. We downloaded all chemicals from all chemists at Kimbell, which is the biggest repository of these things and their activities. Every chemist who published more than, I think it was 30 papers and 600 molecules. So you get all the molecules and all the stuff. It's 1,815 chemists. And then we…
- Lab-in-the-Loop at Compute Speed — Ian Quigley, Leash Bio
- Dyna-2: General Purpose Physical Agents with Hour-Long Autonomy — Jason Ma, Dyna Robotics
- Why AlphaFold Didn't Solve Protein Folding — Pushmeet Kohli, Google DeepMind & Sal Candido, Biohub
- Synthesis Superintelligence: from Semiconductors to Superconductors — Periodic Labs’ Liam Fedus and Ekin Dogus Cubuk
- Academia is for Ambition — Alex Zhang, MIT
- Why Dwarkesh is Wrong about Computer Use + How OpenAI shipped its Jev competitor in 1 Week
- Claude Code’s Next Era — Thariq Shihipar, Anthropic
- OpenRouter: from Seed to Stripe — with OpenRouter’s Alex Atallah & AMP’s Anjney Midha
- Runway’s WorldPrompt and the Engineering of Real-Time Worlds
- 🔬Bio-security is an AI Arms Race - Eric Nguyen (CEO, Radical Numerics)
- 🔬 An Oscar, Two Asteroids, and the Algorithm in Your sklearn: John Platt on AI for Science
- Jev: System One models for Prod, not God — with Diogo Almeida, CEO, TypeSafe AI
- Underwriting Superintelligence: Backing Agents you can Sue — Rune Kvist, AIUC
- Humanity’s Last Invention — Richard Socher of Recursive
- 🔬“We have foundation models for language, not for physics” — Anima Anandkumar, Bren Professor of Computing
- Simulation: the new Scaling Law — Joon Sung Park, Simile AI
- 🔬The BioAI Phase Shift - Matthew McPartlon & Neil Patil, Chai Discovery
- The Inference Engineering Masterclass — Philip Kiely & Ali Taha, Baseten
- Codex from 0 to 10M Users: Building ChatGPT Work — Akshay Nathan, OpenAI
- Inside the Model Factory — Eiso Kant, Poolside AI
- 🔬Causal Models Need Causal Data - Xaira’s X-Cell model for Drug Discovery (Bo Wang & Ci Chu, Chief Discovery Officer & Chief AI Scientist)
- 🔬 The Lab of the Future Should Feel Like a Data Center — Andy Beam & Rafa Gómez-Bombarelli, Lila Sciences
- Why AI Infrastructure must evolve for Agent Experience — Akshat Bubna, Modal CTO
- 🔬 The Coolest Diffusion Research Isn't in LLMs — Evan Feinberg & Sergey Edunov, Genesis Molecular AI
- Why the Frontier Ecosystem must be Open — Matei Zaharia and Reynold Xin, Databricks
- Red-Teaming after Mythos — Zico Kolter & Matt Fredrikson, Gray Swan
- The Professor of Outputmaxxing — Anjney Midha, AMP
- 🔬 The Self-Driving Lab — Joseph Krause, Radical AI
- Reality: The Final Eval — Lukas Petersson and Axel Backlund of Andon Labs
- 🔬Scaling Past Informal AI - Carina Hong, Axiom Math
- ⚡️Satya Nadella: No Priors x Latent Space Crossover Special at Microsoft Build
- GitHub's plan for Agents — Kyle Daigle, GitHub
- Why Video Agent models are next — Ethan He, xAI Grok Imagine
- The Age of Async Agents — Cognition's Walden Yan & OpenInspect's Cole Murray
- 🔬ESM: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub
- Giving Agents Computers — Ivan Burazin, Daytona
- Railway: The Agent-Native Cloud — Jake Cooper
- The Autonomous Drone Tech Stack & Economics of Drones — Yaroslav Azhnyuk, The Fourth Law & Guest Host Noah Smith, Noahpinion
- AI-Native Healthcare: 100M Doctor Visits, 10–20 Hours Saved, Prior Auth in Minutes — Janie Lee & Chai Asawa, Abridge
- 🔬Doing Vibe Physics — Alex Lupsasca, OpenAI
- Physical AI that Moves the World — Qasar Younis & Peter Ludwig, Applied Intuition
- AIE Europe Debrief + Agent Labs Thesis: Unsupervised Learning x Latent Space Crossover Special (2026)
- Shopify’s AI Phase Transition: 2026 Usage Explosion, Unlimited Opus-4.6 Token Budget, Tangle, Tangent, SimGym — with Mikhail Parakhin, Shopify CTO
- 🔬 Training Transformers to solve 95% failure rate of Cancer Trials — Ron Alfa & Daniel Bear, Noetik
- Notion’s Token Town: 5 Rebuilds, 100+ Tools, MCP vs CLIs and the Software Factory Future — Simon Last & Sarah Sachs of Notion
- Extreme Harness Engineering for Token Billionaires: 1M LOC, 1B toks/day, 0% human code, 0% human review — Ryan Lopopolo, OpenAI Frontier & Symphony
- Marc Andreessen introspects on The Death of the Browser, Pi + OpenClaw, and Why "This Time Is Different"
- Moonlake: Causal World Models should be Multimodal, Interactive, and Efficient — with Chris Manning and Fan-yun Sun
- Mistral: Voxtral TTS, Forge, Leanstral, & what's next for Mistral 4 — w/ Pavan Kumar Reddy & Guillaume Lample
- 🔬Why There Is No "AlphaFold for Materials" — AI for Materials Discovery with Heather Kulik
- Dreamer: the Personal Agent OS — David Singleton
- Why Anthropic Thinks AI Should Have Its Own Computer — Felix Rieseberg of Claude Cowork & Claude Code Desktop
- Retrieval After RAG: Hybrid Search, Agents, and Database Design — Simon Hørup Eskildsen of Turbopuffer
- NVIDIA's AI Engineers: Agent Inference at Planetary Scale and "Speed of Light" — Nader Khalil (Brev), Kyle Kranen (Dynamo)
- Cursor's Third Era: Cloud Agents
- Every Agent Needs a Box — Aaron Levie, Box
- METR’s Joel Becker on exponential Time Horizon Evals, Threat Models, and the Limits of AI Productivity
- [LIVE] Anthropic Distillation & How Models Cheat (SWE-Bench Dead) | Nathan Lambert & Sebastian Raschka
- 🔬Searching the Space of All Possible Materials — Prof. Max Welling, CuspAI
- Claude Code for Finance + The Global Memory Shortage: Doug O'Laughlin, SemiAnalysis
- ⚡️The End of SWE-Bench Verified — Mia Glaese & Olivia Watkins, OpenAI Frontier Evals & Human Data
- Bitter Lessons in Venture vs Growth: Anthropic vs OpenAI, Noam Shazeer, World Labs, Thinking Machines, Cursor, ASIC Economics — Martin Casado & Sarah Wang of a16z
- Owning the AI Pareto Frontier — Jeff Dean
- 🔬Beyond AlphaFold: How Boltz is Open-Sourcing the Future of Drug Discovery
- The First Mechanistic Interpretability Frontier Lab — Myra Deng & Mark Bissell of Goodfire AI
- 🔬 Automating Science: World Models, Scientific Taste, Agent Loops — Andrew White
- Captaining IMO Gold, Deep Think, On-Policy RL, Feeling the AGI in Singapore — Yi Tay
- Brex’s AI Hail Mary — With CTO James Reggio
- Artificial Analysis: Independent LLM Evals as a Service — with George Cameron and Micah-Hill Smith
- [State of Evals] LMArena's $1.7B Vision — Anastasios Angelopoulos, LMArena
- [NeurIPS Best Paper] 1000 Layer Networks for Self-Supervised RL — Kevin Wang et al, Princeton
- [State of Code Evals] After SWE-bench, Code Clash & SOTA Coding Benchmarks recap — John Yang
- [State of Post-Training] From GPT-4.1 to 5.1: RLVR, Agent & Token Efficiency — Josh McGrath, OpenAI
- [State of RL/Reasoning] IMO/IOI Gold, OpenAI o3/GPT-5, and Cursor Composer — Ashvin Nair, Cursor
- [State of AI Startups] Memory/Learning, RL Envs & DBT-Fivetran — Sarah Catanzaro, Amplify
- One Year of MCP — with David Soria Parra and AAIF leads from OpenAI, Goose, Linux Foundation
- Steve Yegge's Vibe Coding Manifesto: Why Claude Code Isn't It & What Comes After the IDE
- ⚡️GPT5-Codex-Max: Training Agents with Personality, Tools & Trust — Brian Fioca + Bill Chen, OpenAI
- SAM 3: The Eyes for AI — Nikhila & Pengchuan (Meta Superintelligence), ft. Joseph Nelson (Roboflow)
- ⚡️Jailbreaking AGI: Pliny the Liberator & John V on Red Teaming, BT6, and the Future of AI Security
- AI to AE's: Grit, Glean, and Kleiner Perkins' next Enterprise AI hit — Joubin Mirzadegan, Roadrunner
- The Future of Email: Superhuman CTO on Your Inbox As the Real AI Agent (Not ChatGPT) — Loïc Houssier
- World Models & General Intuition: Khosla's largest bet since LLMs & OpenAI
- After LLMs: Spatial Intelligence and World Models — Fei-Fei Li & Justin Johnson, World Labs
- ⚡️ 10x AI Engineers with $1m Salaries — Alex Lieberman & Arman Hezarkhani, Tenex
- Anthropic, Glean & OpenRouter: How AI Moats Are Built with Deedy Das of Menlo Ventures
- ⚡ Inside GitHub’s AI Revolution: Jared Palmer Reveals Agent HQ & The Future of Coding Agents
- ⚡ [AIE CODE Preview] Inside Google Labs: Building The Gemini Coding Agent — Jed Borovik, Jules
- ⚡️ Ship AI recap: Agents, Workflows, and Python — w/ Vercel CTO Malte Ubl
- Why RL Won — Kyle Corbitt, OpenPipe (acq. CoreWeave)
- DevDay 2025: Apps SDK, Agent Kit, MCP, Codex and why Prompting is More Important than Ever
- Taste is your Moat (Dylan Field of Figma)
- Amp: The Emperor Has No Clothes
- Context Engineering for Agents - Lance Martin, LangChain
- Better Data is All You Need — Ari Morcos, Datology
- The RLVR Revolution — with Nathan Lambert (AI2, Interconnects.ai)
- AI is Eating Search
- Cline: the open source coding agent that doesn't cut costs
- Personalized AI Language Education — with Andrew Hsu, Speak
- AI Video Is Eating The World — Olivia and Justine Moore, a16z
- Information Theory for Language Models: Jack Morris
- Scaling Test Time Compute to Multi-Agent Civilizations — Noam Brown, OpenAI
- The Utility of Interpretability — Emmanuel Amiesen
- [AIEWF Preview] Containing Agent Chaos — Solomon Hykes
- [AIEWF Preview] Gemini in 2025 and Realtime Voice AI
- [AIEWF Preview] CloudChef: Your Robot Chef - Michellin-Star food at $12/hr (w/ Kitchen tour!)
- The AI Coding Factory
- [AIEWF Preview] Multi-Turn RL for Multi-Hour Agents — with Will Brown, Prime Intellect
- ⚡️The Rise and Fall of the Vector DB Category
- ⚡️GPT 4.1: The New OpenAI Workhorse
- SF Compute: Commoditizing Compute to solve the GPU Bubble forever
- The Creators of Model Context Protocol
- The Agent Network — Dharmesh Shah
- Building Snipd: The AI Podcast App for Learning
- ⚡️The new OpenAI Agents Platform
- ⚡️How Claude 3.7 Plays Pokémon
- Open Operator, Serverless Browsers and the Future of Computer-Using Agents
- The Inventors of Deep Research
- Bee AI: The Wearable Ambient Agent
- The AI Architect — Bret Taylor
- Agent Engineering with Pydantic + Graphs — with Samuel Colvin
- The Agent Reasoning Interface: o1/o3, Claude 3, ChatGPT Canvas, Tasks, and Operator — with Karina Nguyen of OpenAI
- Outlasting Noam Shazeer, crowdsourcing Chai AI with >1.4m DAU, and becoming the "Western DeepSeek" — with William Beauchamp, Chai Research
- Everything you need to run Mission Critical Inference (ft. DeepSeek v3 + SGLang)
- Beating Google at Search with Neural PageRank and $5M of H200s — with Will Bryk of Exa.ai
- AI Engineering for Art — with comfyanonymous, of ComfyUI
- Latent.Space 2024 Year in Review
- 2024 in Agents [LS Live! @ NeurIPS 2024]
- 2024 in Synthetic Data and Smol Models [LS Live @ NeurIPS]
- 2024 in Post-Transformers Architectures (State Space Models, RWKV) [LS Live @ NeurIPS]
- 2024 in Open Models [LS Live @ NeurIPS]
- 2024 in Vision [LS Live @ NeurIPS]
- 2024 in AI Startups [LS Live @ NeurIPS]
- Windsurf: The Enterprise AI IDE - with Varun and Anshul of Codeium AI
- Bolt.new, Flow Engineering for Code Agents, and >$8m ARR in 2 months as a Claude Wrapper
- The new Claude 3.5 Sonnet, Computer Use, and Building SOTA Agents — with Erik Schluntz, Anthropic
- Why Compound AI + Open Source will beat Closed AI
- Agents @ Work: Lindy.ai
- Agents @ Work: Dust.tt
- In the Arena: How LMSys changed LLM Benchmarking Forever
- How NotebookLM Was Made
- Building the AI Engineer Nation — with Josephine Teo, Minister of Digital Development and Information, Singapore
- Building the Silicon Brain - with Drew Houston of Dropbox
- Production AI Engineering starts with Evals — with Ankur Goyal of Braintrust
- Building AGI in Real Time (OpenAI Dev Day 2024)
- Language Agents: From Reasoning to Acting
- The Ultimate Guide to Prompting
- From API to AGI: Structured Outputs, OpenAI API platform and O1 Q&A — with Michelle Pokrass & OpenAI Devrel + Strawberry team
- Efficiency is Coming: 3000x Faster, Cheaper, Better AI Inference from Hardware Improvements, Quantization, and Synthetic Data Distillation
- Why you should write your own LLM benchmarks — with Nicholas Carlini, Google DeepMind
- Is finetuning GPT4o worth it? — with Alistair Pullen, Cosine (Genie)
- AI Magic: Shipping 1000s of successful products with no managers and a team of 12 — Jeremy Howard of Answer.ai
- Segment Anything 2: Demo-first Model Development
- The Winds of AI Winter (Q2 Four Wars Recap) + ChatGPT Voice Mode Preview
- Llama 2, 3 & 4: Synthetic Data, RLHF, Agents on the path to Open Source AGI
- Benchmarks 201: Why Leaderboards > Arenas >> LLM-as-Judge
- The 10,000x Yolo Researcher Metagame — with Yi Tay of Reka
- State of the Art: Training >70B LLMs on 10,000 H100 clusters
- [High Agency] AI Engineer World's Fair Preview
- How To Hire AI Engineers — with James Brady & Adam Wiggins of Elicit
- How AI is eating Finance — with Mike Conover of Brightwave
- ICLR 2024 — Best Papers & Talks (Benchmarks, Reasoning & Agents) — ft. Graham Neubig, Aman Sanger, Moritz Hardt)
- How to train a Million Context LLM — with Mark Huang of Gradient.ai
- ICLR 2024 — Best Papers & Talks (ImageGen, Vision, Transformers, State Space Models) ft. Durk Kingma, Christian Szegedy, Ilya Sutskever
- Emulating Humans with NSFW Chatbots - with Jesse Silver
- WebSim, WorldSim, and The Summer of Simulative AI — with Joscha Bach of Liquid AI, Karan Malhotra of Nous Research, Rob Haisfield of WebSim.ai
- High Agency Pydantic > VC Backed Frameworks — with Jason Liu of Instructor
- Supervise the Process of AI Research — with Jungwon Byun and Andreas Stuhlmüller of Elicit
- Latent Space Chats: NLW (Four Wars, GPT5), Josh Albrecht/Ali Rohde (TNAI), Dylan Patel/Semianalysis (Groq), Milind Naphade (Nvidia GTC), Personal AI (ft. Harrison Chase — LangFriend/LangMem)
- Presenting the AI Engineer World's Fair — with Sam Schillace, Deputy CTO of Microsoft
- Why Google failed to make GPT-3 + why Multimodal Agents are the path to AGI — with David Luan of Adept
- Making Transformers Sing - with Mikey Shulman of Suno
- Top 5 Research Trends + OpenAI Sora, Google Gemini, Groq Math (Jan-Feb 2024 Audio Recap) + Latent Space Anniversary with Lindy.ai, RWKV, Pixee, Julius.ai, Listener Q&A!
- Open Source AI is AI we can Trust — with Soumith Chintala of Meta AI
- A Brief History of the Open Source AI Hacker - with Ben Firshman of Replicate
- Truly Serverless Infra for AI Engineers - with Erik Bernhardsson of Modal
- Cloud Intelligence at the speed of 5000 tok/s - with Ce Zhang and Vipul Ved Prakash of Together AI
- Why StackOverflow usage is down 50% — with David Hsu of Retool
- The Four Wars of the AI Stack (Dec 2023 Audio Recap)
- How to train your own Large Multimodal Model — with Hugo Laurençon & Leo Tronchon of HuggingFace M4
- RLHF 201 - with Nathan Lambert of AI2 and Interconnects
- The Accidental AI Canvas - with Steve Ruiz of tldraw
- NeurIPS 2023 Recap — Top Startups
- NeurIPS 2023 Recap — Best Papers
- The AI-First Graphics Editor - with Suhail Doshi of Playground AI
- The "Normsky" architecture for AI coding agents — with Beyang Liu + Steve Yegge of SourceGraph
- The Busy Person's Intro to Finetuning & Open Source AI - Wing Lian, Axolotl
- Notebooks = Chat++ and RAG = RecSys! — with Bryan Bischof of Hex Magic
- The State of Silicon and the GPU Poors - with Dylan Patel of SemiAnalysis
- AGI is Being Achieved Incrementally (DevDay Recap - cleaned audio)
- AGI is Being Achieved Incrementally (OpenAI DevDay w/ Simon Willison, Alex Volkov, Jim Fan, Raza Habib, Shreya Rajpal, Rahul Ligma, et al)
- Beating GPT-4 with Open Source LLMs — with Michael Royzen of Phind
- Powering your Copilot for Data – with Artem Keydunov of Cube.dev
- The End of Finetuning — with Jeremy Howard of Fast.ai
- Why AI Agents Don't Work (yet) - with Kanjun Qiu of Imbue
- [AIE Summit Preview #2] The AI Horcrux — Swyx on Cognitive Revolution
- [AIE Summit Preview #1] Swyx on Software 3.0 and the Rise of the AI Engineer
- RAG Is A Hack - with Jerry Liu from LlamaIndex
- Heralds of the AI Content Flippening — with Youssef Rizk of Wondercraft.ai
- Doing it the Hard Way: Making the AI engine and language 🔥 of the future — with Chris Lattner of Modular
- The Point of LangChain — with Harrison Chase of LangChain
- RWKV: Reinventing RNNs for the Transformer Era — with Eugene Cheah of UIlicious
- Cursor.so: The AI-first Code Editor — with Aman Sanger of Anysphere
- The Mathematics of Training LLMs — with Quentin Anthony of Eleuther AI
- LLMs Everywhere: Running 70B models in browsers and iPhones using MLC — with Tianqi Chen of CMU / OctoML
- [AI Breakdown] Summer AI Technical Roundup: a Latent Space x AI Breakdown crossover pod!
- FlashAttention 2: making Transformers 800% faster w/o approximation - with Tri Dao of Together AI
- Llama 2: The New Open LLM SOTA (ft. Nathan Lambert, Matt Bornstein, Anton Troynikov, Russell Kaplan, Whole Mars Catalog et al.)
- AI Fundamentals: Datasets 101
- Code Interpreter == GPT 4.5 (w/ Simon Willison, Alex Volkov, Aravind Srinivas, Alex Graveley, et al.)
- [Practical AI] AI Trends: a Latent Space x Practical AI crossover pod!
- [Cognitive Revolution] The Tiny Model Revolution with Ronen Eldan and Yuanzhi Li of Microsoft Research
- Commoditizing the Petaflop — with George Hotz of the tiny corp
- Emergency Pod: OpenAI's new Functions API, 75% Price Drop, 4x Context Length (w/ Alex Volkov, Simon Willison, Riley Goodside, Joshua Lochner, Stefania Druga, Eric Elliott, Mayo Oshin et al)
- From RLHF to RLHB: The Case for Learning from Human Behavior - with Jeffrey Wang and Joe Reeve of Amplitude
- Building the AI × UX Scenius — with Linus Lee of Notion AI
- Debugging the Internet with AI agents – with Itamar Friedman of Codium AI and AutoGPT
- MPT-7B and The Beginning of Context=Infinity — with Jonathan Frankle and Abhinav Venigalla of MosaicML
- Guaranteed quality and structure in LLM outputs - with Shreya Rajpal of Guardrails AI
- No Moat: Closed AI gets its Open Source wakeup call — ft. Simon Willison
- Training a SOTA Code LLM in 1 week and Quantifying the Vibes — with Reza Shabani of Replit
- Mapping the future of *truly* Open Models and Training Dolly for $30 — with Mike Conover of Databricks
- AI-powered Search for the Enterprise — with Deedy Das of Glean
- AI Fundamentals: Benchmarks 101
- Grounded Research: From Google Brain to MLOps to LLMOps — with Shreya Shankar of UC Berkeley
- Emergency Pod: ChatGPT's App Store Moment (w/ OpenAI's Logan Kilpatrick, LindyAI's Florent Crivello and Nader Dabit)
- From Astrophysics to AI: Building the future AI Data Stack — with Sarah Nagy of Seek.ai
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