Could *This* Molecule Be the KEY To Reversing Immune Aging & “Supercharging” Your Mitochondria? With Dr. Anurag Singh

**Ben Greenfield** (0:00)
My name is Ben Greenfield, and on this episode of the Boundless Life podcast.

**Anurag Singh** (0:05)
You know, when you take your eulatinae, not only are you hitting mitochondria in your skeletal muscle cells, but what we are discovering is that the mitochondria in inside the immune cells, they get recharged, and they kind of propel the immune system at a much better way.

**Ben Greenfield** (0:22)
Welcome to the Boundless Life, with me, your host, Ben Greenfield. I'm a personal trainer, exercise physiologist, and nutritionist, and I'm passionate about helping you discover unparalleled levels of health, fitness, longevity, and beyond.
You might be familiar with my book, Boundless, Upgrade Your Brain, Optimize Your Body and Defy Aging. It got a little out of control writing it. The original manuscript is over 1500 pages. I got it down to like 700 pages and released it several months ago, about a year ago, the fully updated version of Boundless, kind of like the Bible of biohacking, a cookbook for everything you'd ever want, hormones, gut, digestion, et cetera. And I realize it's a little bit intimidating to pick up and read. And here's why I'm telling you all of this. I am curious if you would like the audio book version of Boundless, like on Audible or elsewhere for you to download, listen to at your convenience in the gym, on your commute, on your hike, while you're cleaning your kitchen, in the bath sub, taking a crap. I don't know whenever you listen to an audio book. So anyways, if that is remotely interesting to you and you want me to make that audio book happen so that you can have it in your ears wherever you go, go to bengreenfieldlife.com/boundlessaudio, bengreenfieldlife.com/boundlessaudio, your opinion matters. There is one molecule that's kind of been taking the health, longevity and mitochondrial world by storm lately. You may have heard of it before. You'll hear more about it in today's show in deep diving detail. There's your alliteration for the day. My podcast is with Dr. Singh. We're going to be talking about, drum roll please. You're about to find out for boosting muscle and endurance and reversing immune aging. So these show notes are going to be at bengreenfieldlife.com/timelinereplay.
That's bengreenfieldlife.com/timelinereplay.
Let's jump in. Dr. Singh, welcome back, man.

**Anurag Singh** (2:44)
Pleasure, Ben. Absolute pleasure to be back on.

**Ben Greenfield** (2:46)
Yeah. Yeah, and in our last show, we talked a lot about the human performance enhancing effects of urolithin A, especially related to strength and endurance. I've been supplementing with it at about 500 to a thousand milligrams a day since I talked with you.
Fortunately, it's a little tastier now. I'm addicted to these little 250 milligram gummies that you guys make, these strawberry gummies. I just had them in my smoothie. But now it appears there is immunity data. I want to dive into that, but just for people who didn't hear our last podcast, what is the scope of the effects in terms of human performance when you look at something like urolithin A?

**Anurag Singh** (3:28)
Sure.
Just as a reminder, this is 15 years of very in-depth biotech research that basically discovered this post-biotic molecule, correct? Urolithin A is the molecule in Mitopure, it's branded name. Fifteen years in a snapshot, what we started finding was that this post-biotic urolithin A activates a process within a body that slows down with edging, and this process is called mitophagy, which is basically cleaning up of damaged zombie mitochondria similar to autophagy of the cell, right? And so what happens with this reactivation of mitophagy, if you're supplementing with urolithin A or Mitopure, is that the damaged mitochondria get recycled into healthier ones that basically produce more energy. And so instead of getting fatigued, instead of having poor endurance with aging, what we see across species and in multiple randomized trials now, is that regular supplementation for up to two to four months, we see in healthy adults, whether it's 40s, 50, 60 year olds or even older adults, we see primarily a big benefit on improved muscle strength in the legs, and we see better endurance, so better peak VO2, better recovery from exercise, etc. So that's the scope and depth of the trials we had talked about. Lately, there are-

**Ben Greenfield** (4:57)
Just to interrupt real quick, was that at about a thousand milligrams?

**Anurag Singh** (5:01)
Yeah.
We studied what is called as dose finding clinical studies, and we find that the sweet spot is between 500 milligrams to about a gram. 500 milligram dose is where we start seeing the activation of mitophagy and the improvement in myocondrial health, and longer term usage and improvements in strength. But the gram dose really takes it up a notch in terms of the benefits we start seeing. In addition to the strength benefits, we see better endurance, and we can talk about it, more impact on systemic aging and systemic organs, such as immune aging.