AMA with Dom D'Agostino, Ph.D., Part I of II: Ketogenic diet, exogenous ketones, and exercise

**Peter Attia** (0:11)
Hey, everyone, welcome to a sneak peek, Ask Me Anything, or AMA episode of the Drive podcast. I'm your host, Peter Attia. At the end of this short episode, I'll explain how you can access the AMA episodes in full, along with a ton of other membership benefits we've created. Or you can learn more now by going to peterattiamd.com forward slash subscribe. So without further delay, here's today's sneak peek of the Ask Me Anything episode.
Hey everyone, welcome to a special Ask Me Anything episode. And when I say special, I am not kidding. You'll see why in a moment.
This is going to be part of a two part series with Dom D'Agostino. Now some of you may know Dom's name as he was, oh, I don't know, probably our fifth guest when this podcast kicked off in 2018 Dom's episode To This Day remains one of our most popular episodes. And it's for that reason that we decided to go back and bring him back on in the format of a Q&A. We had this interview scheduled for a long time. And right when it was scheduled to happen, something came up, something very important came up where I had to go away. And I had to go away such that I couldn't actually do the interview.
We all pow wowed and contemplated, should we reschedule it for a little while? Dom had already set aside the time to do it. And in the end, the consensus view was, why not have Bob Kaplan, who many of you know from this podcast, why not have Bob do it? Bob and Dom already have a great rapport. There's probably nothing here that Bob would do that I wouldn't do and vice versa. So Bob and Tom ended up doing just that. And they ended up sitting down for a heck of a lot longer than anticipated. Both true to the sport, Bob wanted to go down every avenue and Dom left no stone unturned. And that's why it's being divided into two parts, so that a normal human being could actually listen to it in a reasonable sitting. Now in the first episode, Bob and Tom cover a lot of questions, both general and specific about ketogenic diets and ketosis. They also do a bit of a deep dive on the impact of ketosis on different forms of exercise. Now as a reminder, Dom is an associate professor at the University of South Florida, where he teaches at the College of Medicine and the Department of Molecular Pharmacology and Physiology. He focuses on neuropharmacology, medical, biochemistry, physiology, neuroscience, neuropharmacology. As a reminder, I believe Dom actually got his PhD in neurobiology. For those of you who haven't listened to it, it might even be worth going back and listening to at least part of the first discussion I had with Dom in 2018, because it gives you an idea of how a neuroscientist became one of the most credible voices on ketosis, ketogenic diets and all things ketone related.
Lastly, it is important to note that while Dom is answering specific questions and scenarios, he is not giving medical advice. Everything in this podcast is for general informational purposes only and does not constitute the practice of medicine, including the giving of medical advice.
So without further delay, please enjoy part one of the AMA with Dom D'Agostino.

**Bob Kaplan** (3:23)
All right, welcome to a very special AMA with Dom D'Agostino. Dom, how are you doing?

**Dom D'Agostino** (3:28)
I'm doing well. Thanks for having me.

**Bob Kaplan** (3:30)
Absolutely. So it's been almost two years since you were on the podcast with Peter.
I met you in New York at that time. I think it was the summer of 2018

**Dom D'Agostino** (3:40)
I know how time flies. I was just talking to my wife about that. She had asked me what I'm doing this week and I said, oh, I got the podcast with Peter Attia. She's like, didn't you just do one?
And I mean, she was happy that it was on, but we were just amazed at how fast that time flew by. Yeah, the time in New York. So I give you credit for dealing with New York. It's always an adventure every time we go.

**Bob Kaplan** (4:03)
Absolutely. So since then, we certainly received a bundle of questions. And then Peter went on social media and asked if there were any questions for you and particularly what you've been up to in the last couple of years.
But maybe you could fill us in just in general, a little bit about ketosis or how did you get into ketosis and what you've been up to in the last couple of years. Sure.