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Imants Podcast Transcripts

Imants Zudans · 2 episodes with transcripts

Thousands of companies develop new therapies. But behind every one of them are the companies that make the work possible. They build the software, supply the reagents, run the experiments, develop the analytical methods. They create new algorithms, new approaches, better services.

Spoken has transcripts of 2 Imants Podcast episodes, with the speakers named. The newest listed here is from April 30, 2026.

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Latest Imants Podcast transcripts

The StarDrop Story with Matt Segall, Optibrium

April 30, 2026

Imants Zudans (0:00)

Welcome to Imants Podcast. I am Imants Zudans. I interview founders building tools for drug discovery.

My guest today is Matt Segall, founder of Optibrium. Matt is a physicist, not a chemist. He builds software that helps medicinal chemists make better decisions about which compounds to pursue. There is no founding moment in this story. No garage, no eureka. Matt spent over a decade trying to bring these tools to…

Matt Segall (1:26)

Thanks very much, Imants. It's great to be here. Well, it feels like a very long time ago now. But it essentially started when I was doing a postdoc at Cambridge University. Although I was a theoretical physicist, I was actually working on modeling drug metabolism using first principles quantum mechanics, so really…

We started working with them on building predictive ad-met models. I was particularly focused on drug metabolism along with the group obviously in California, but we were looking at how we predict a broader range of ad-met properties. Back in those days, what's now absolutely standard in terms of QSAR models for…

Imants Zudans (3:18)

So you said that at that time that was a kind of novel idea, not conventional. How come?

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