You Can Reverse Aging with Muscle | Kevin Murach PhD

**Dr. Gabrielle Lyon** (0:02)
Welcome to The Dr. Gabrielle Lyon Show, where I believe a healthy world is based on transparent conversations.
In today's episode of The Dr. Gabrielle Lyon Show, I sit down with Kevin Murach, Ph.D. He received a master's degree in Exercise Physiology at James Madison University in Virginia. He then earned his Ph.D. in Human Bioenergetics from the Ball State Human Performance Laboratory in Indiana. His dissertation, which we talk about in this episode, was a collaboration with NASA aimed at optimizing the exercise prescription for astronauts on the International Space Station. After Ball State, he spent six years as a postdoctoral fellow and scholar studying one of my favorite topics, muscle stem cells, at the University of Kentucky Center for Muscle Biology in Lexington. He is now an assistant professor at the University of Arkansas. He has a lab, it's called M3R, which stands for Muscle Mass Regulation. What I love about this conversation is it really highlights the basic science. We talk about nutrition, we talk about exercise. Kevin does so well, is examine some of the genetic and epigenetic expressions of what exercise does. We spoke about the Yamanaka factor. These are the factors that we think about from an age reversal and quote regeneration perspective. We also discuss what is DNA methylation? We're hearing a lot about methylation and how does that relate to the aging and adaptation of skeletal muscle? And finally, how does exercise improve longevity from a genetic and epigenetic expression? I hope you love this episode. As always, we provide this content free. It would mean the world to me and our team. If you share it, leave us a review. We would love your feedback. Our goal is to educate. Let's dive in to this episode. Thank you to AquaTru for sponsoring this episode of the show. Having clean, healthy water is a non-negotiable in our household, but the tap water that you drink oftentimes has contaminants. It depends on the city that you live in, where your location is. We are an advancing society, and with advancements, we are getting more and more chemical byproducts and things like PFAS and other contaminants found in our water. AquaTru has a capacity to remove 15 times more contaminants than ordinary pitcher filters. AquaTru is specifically designed to combat chemicals. This makes a fantastic useful gift for people. Give them something that they absolutely can use and will help make them healthier. I even give filtered water to my plants. If you have pets, pets should be having filtered water, and AquaTru does a fantastic job. These filters, they last anywhere from six months to two years.
Really just incredible.
My listeners get 20% off and a 30-day money-back guarantee. Head on over to aquatru.com. That's aquatru.com.
Enter the code DRLYON at checkout and you will receive 20% off. Thank you to Timeline Nutrition for sponsoring this episode of the show.
I am totally hooked on Mitopur. If I were to create a supplement, this certainly would be it.
Mitopur, which is something called Urolithin A, helps our mitochondria produce energy more efficiently. It triggers our body's natural cellular renewal process. It replaces damaged mitochondria with fresh new ones, this process called Mitophagy.
This is thoroughly researched.
It has over a decade of peer-reviewed science. I strongly suggest that you guys look in PubMed. You can actually find these papers. You can try it yourself for the health of your skeletal muscle.
Head on over to timelinenutrition.com/dr. Lyon. You will get 10% off your first order. This is an absolutely incredible, incredible supplement. It comes in capsule form. It also has a beautiful product line that has a mito pure berry or ginger powder. You can mix this in your daily smoothie. Again, it is made with urelythin A. Urelythin A is a postbiotic that helps with mitochondrial health, giving you more energy, improving muscle function and health. Head on over to timelinenutrition.com/dr. Lyon for 10% off your first order. Dr. Kevin Murach, thank you so much for joining us. I am thrilled and a shout out to Dr. Chris Frye, who made the introduction. We are excited to talk about all things skeletal muscle, skeletal muscle epigenetics. You are doing some very innovative work.
I would love for you to tell the audience a little bit about your lab. I see that you have got a M3 shirt on.

**Kevin Murach** (5:51)
Yep, that's my lab. Yep.

**Dr. Gabrielle Lyon** (5:52)
I want to hear everything that you are doing.

**Kevin Murach** (5:55)
Yeah. So again, my name is Kevin Murach. I've been studying skeletal muscle for about a little over a decade for sure. So I did some of my education, my early education at UNC, which, you know, Chapel Hill, basketball and all that, so that was my undergraduate in Exercise Sports Science and a master's degree in Exercise Physiology from James Madison University. Then I did my Ph.D. at Ball State, which is the longest running still open human performance laboratory in America. It was a lot of skeletal muscle human work that we were interested in at that time. Then I spent six years, as you mentioned, Chris Fry, who is currently at the University of Kentucky, I spent six years there as a post-doc, and that's where Chris and I crossed paths. Just to close that loop, that's where that came from. Chris is a collaborator, friend, and mentor. He's a great guy, so I look forward to listening to his podcast. Then I started my own laboratory at the University of Arkansas in 2021 We've been interested in trying to study skeletal muscle adaptation to exercise with a specific emphasis in aging, trying to understand how age muscle can become more like younger people's muscle. We've been trying to explore that using a lot of different molecular biology and biochemical techniques.