Why Your Cholesterol Is High—and How to Start Fixing It in 10 Days artwork

Why Your Cholesterol Is High—and How to Start Fixing It in 10 Days

The Dr. Hyman Show

June 8, 2026

High cholesterol is one of the most common reasons people are told they’re at risk for heart disease. But what if cholesterol isn’t the root problem?
Speakers: Dr. Mark Hyman, Dr. Aseem Malhotra
**Dr. Mark Hyman** (0:00)
What if brain fog, anxiety, and mood swings aren't simply all in your head? What if the health of your mind actually starts deeper in your body, in your gut, in your hormones, metabolism, and your immune system? Well, let me tell you, the connection is real, and it affects how you think and you feel every single day. And that's why I created Brain Shaping Academy, a six-week program that shows you how healing your body can help you heal your mind. Brain Shaping Academy relies on the same target nutrition and lifestyle strategies I've used for 30 years to help my patients improve their mental, emotional, and cognitive health. So if you want to feel calmer, clearer, and more in control, and stay sharp and protect your brain as you age, check out Brain Shaping Academy at drhyman.com/brainshaping.
That's drhyman.com/brainshaping.
Welcome to Office Hours. This is our dedicated 101 space to go deeper, get clearer and explore what truly moves the needle for your health. I'm Dr. Mark Hyman, and each week, we're gonna pull back the curtain and share the insights, the research, the lessons that don't always make it into our conversations with guests.
Because at the end of the day, you are the CEO of your own health. And for many of you, your family's health too.
And you might not feel it all the time, but you have far more power and agency than you realize. I'm glad you're here.
This episode is brought to you by Function Health, empowering you to live 100 healthy years with over 160 lab tests for just $365 a year. And use the code MARK2026 to get $50 off your membership.
You get your lab results back and your cholesterol is high. And almost immediately, the conversation goes in one direction. Lower your cholesterol, cut fat, start a medication. But what if that's not the full picture? What if cholesterol isn't the root problem at all? It's just a deeper signal of something going on in your body. What if in just 10 days, you could start shifting that in the right direction? Not by chasing a number, but by fixing what's driving it in the first place. In functional medicine, we look at cholesterol in a very different way. We don't just ask, how do we lower this number? We ask, why is it elevated? Because cholesterol is not happening in isolation. It's influenced by your blood sugar, your insulin levels, your inflammation, your diet, your gut health, your lifestyle. So instead of chasing cholesterol directly, we focus on fixing this system. And when you do that, cholesterol often improves as a byproduct of better health. So what's really driving cholesterol? Let's take a step back and look at this through a functional medicine lens. Because for many people, high cholesterol isn't about being driven by dietary fat the way we've traditionally been told. It's being driven by deeper imbalances in the body, things like insulin resistance, too much sugar and refined carbs, chronic low-grade inflammation, ultra-processed foods, and a lack of movement throughout the day. These are the real drivers for a large percentage of people. And here's where it gets interesting. For many people, sugar and processed carbs are actually a bigger problem than fat because of what they do metabolically. When you eat a diet high in starch and sugar, you spike your blood sugar, and that triggers insulin. And over time, consistently elevated insulin can lead to something called insulin resistance. And insulin resistance changes how your body handles fat and cholesterol. It can increase the production of triglycerides. It can alter LDL particles.
It can drive the kind of inflammation that contributes to cardiovascular risk. So now we understand cholesterol isn't the root problem. It's just a downstream effect of metabolic dysfunction. And you have layered on top of that lots of things. Inflammation from poor diet, from stress, and from environmental exposures, all of which further disrupt how your body regulates cholesterol. So when you put all this together, high cholesterol is less about the cholesterol itself and more about what's happening underneath. Your metabolism, your blood sugar, inflammation, your overall lifestyle. And once you start to see it through that lens, well, it changes the question. Instead of asking, how do I lower my cholesterol, the better question becomes, how do I fix what's driving it? Because when you address the root causes, cholesterol often improves as a byproduct. So once you understand what's actually driving your high cholesterol, the next question becomes, what can you do about it starting right now? The good news is that your body can begin changing surprisingly quickly. In fact, many people start noticing meaningful differences in as little as 10 days. And this isn't about restriction. It's not about doing something extreme or unsustainable. It's about creating a short, focused reset, where you reduce inflammation, you stabilize your blood sugar, and you support your metabolism with the right inputs.

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