What We Got Wrong About GLP-1s (And What's Right) | Dr. Tyna Moore artwork

What We Got Wrong About GLP-1s (And What's Right) | Dr. Tyna Moore

The Dr. Hyman Show

August 12, 2026

GLP-1 medications have changed how we treat obesity and metabolic disease. But as their use has exploded, so have questions about side effects, muscle loss, long-term use, and whether patients are receiving the support they need to use them safely.
Speakers: Dr. Mark Hyman, Dr. Tyna Moore

Topics: Medicine, Health & Fitness, Nutrition

**Dr. Mark Hyman** (0:00)
I've changed my opinion over the years on this. At first, I was skeptical, and I've changed my position.

**Dr. Tyna Moore** (0:05)
And I think the one thing that this whole journey has showed all of us is that metabolic health is the core of everything. These peptides improve metabolic health overall. And when we see metabolic health improve, we see all kinds of everything across the board, regardless of weight loss. Irrespective of weight loss, we're seeing really great benefits happen. And yes, there's direct mechanisms of GLP-1s. They land on immune cells. They land on receptors around the body. They have a direct impact that we don't even fully understand.

**Dr. Mark Hyman** (0:31)
Yeah, I think that's a really important framework for people to understand GLP-1s, because a lot of doctors just prescribe them. These are, I think, a real benefit to humanity. The question is, how do we use them right?
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Before we begin, I'd like to note that today's conversation explores one perspective of an area of medicine that continues to be actively debated. And while we discuss emerging evidence and critiques of current psychiatric practice, treatment decisions, especially involving antidepressants or other prescription medications, should always be made in consultation with your health care provider. The views expressed by my guest are her own and reflect her interpretation of the available evidence. My goal in hosting conversations like this is to explore different perspectives, to examine the science, to encourage thoughtful discussion, not to provide individualized medical advice. So if you're currently taking medication, please don't stop or change your treatment based on this conversation alone. Instead, use this episode as a starting point for an informed conversation with your health care team. My hope is that these discussions encourage curiosity, critical thinking and shared decision making between patients and their clinicians.
So before we wrap up, if you found today's conversation on Lyme disease helpful, be sure to check out my upcoming conversation with one of the world's leading Lyme experts, Dr. Richard Horowitz. We go beyond Lyme disease itself to explore why so many people remain chronically ill. We explore his groundbreaking EmSense framework for understanding chronic disease. We also look at the biggest drivers of chronic inflammation and what it really takes to help the body heal. So be sure to check it out this Wednesday. Here's a preview.
If you enjoyed today's episode, don't miss my upcoming conversation with Lyme disease expert Dr. Richard Horowitz. We dive into why so many people stay sick, and we look at the hidden drivers of chronic illness and a whole new way of thinking about inflammation and recovery and healing. It drops this Wednesday and until then, here's a preview of what's to come.
All right, Tina, great to have you back on the podcast. Good to see you again. How are you doing?

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