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The Testosterone, Weight Loss & Hormone Lies Your Doctor Never Told You | Brigham Buhler artwork

The Testosterone, Weight Loss & Hormone Lies Your Doctor Never Told You | Brigham Buhler

The Dr. Josh Axe Show

October 1, 2026

Who decides which treatments you can access—and at what cost? Ways2Well founder Brigham Buhler joins Dr. Josh Axe to discuss pharmacy benefit managers, prescription pricing, and his fight for peptide access.

Speakers Brigham Buhler, Dr. Josh Axe

TopicsNutritionHealth & FitnessAlternative Health

Brigham Buhler (0:00)

Let's look at SSRIs. 25 years later, in retrospective analysis, SSRIs barely differentiate from placebo.

Dr. Josh Axe (0:08)

I remember seeing on Joe Rogan, him holding up those bags of yellow stuff.

Brigham Buhler (0:13)

It's funny because it's being touted as like new technology, but it's old technology being repurposed and utilized for new approaches to medicine.

Dr. Josh Axe (0:20)

You know, so many people, they want the best care, but insurance doesn't cover the best care. They cover sort of like really the worst care.

Brigham Buhler (0:27)

Your health insurance is like car insurance. It's great if you total the car, but if you're expecting it to rotate the tires, change the oil and maintain the vehicle, you are going to be sorely disappointed. What happened in the 90s is those entities were captured by the Big Five Insurance companies. The reason that is a crucial puzzle piece to understand for your listeners, at that point in time, they went away from negotiating down the price of a prescription drug to negotiating up the price of a prescription drug.

Dr. Josh Axe (1:11)

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If you're interested in peptides, ozone therapy, IV nutrients, and anything in the natural medicine world, today I've got an incredible guest, Brigham Buhler. I met him at the HHS headquarters in Washington, DC. And he's been seen on the Joe Rogan podcast. In fact, have you ever seen that clip where Joe Rogan's holding up a bag of yellow stuff? It is actually plasma. It's the post plasma exchange, all of the gunk that's in your blood right now. That's Brigham's clinic. And so today we're going to talk about the power of natural medicine. We'll talk about the future of peptides.

Brigham, welcome to the show.

Brigham Buhler (2:57)

Thank you for having me.

Dr. Josh Axe (2:58)

Well, man, hey, I'm so excited you're able to come up here. I know you're in Austin. And so we were talking about how everybody's moving to Austin or Miami or Nashville.

Brigham Buhler (3:06)

They're the hotbeds. It's nuts.

Dr. Josh Axe (3:08)

Yeah. Great people.

And super excited you're on. I remember seeing you on Joe Rogan. I think you've been on there a couple of times. And him holding up those bags of yellow stuff.

Let's start there just for a minute. I'd love to ask you about Plasma Furesis, also known as Therapeutic Plasma Exchange. And this is a therapy that more, I mean, it's been around for quite a while, but more and more people are now doing it for, you know, essentially blood filtration and detoxification.

Brigham Buhler (3:37)

Yeah, it's a great tool.

And there's tons of tools in the tool, but one of the things that I try to explain to the general public is oftentimes medications, treatments, or even a treatment modality in a primary care practice or traditional medicine practice, they won't get offered that, not because it doesn't work or not because it's not efficacious, but just because it's not covered by the insurance model. So traditionally, those machines were used sometimes in hospital systems to detoxify burn victims. They've been used for over 25 years. So it's funny because it's being touted like new technology, but it's old technology being repurposed and utilized for new approaches to medicine.

Dr. Josh Axe (4:19)

Well, so funny. So when I started my, I started a clinic here about six months ago in Nashville called the Longevity Clinic. And we do a lot of these therapies there. And the nurse I hired came over from Duke. She was in the oncology department there. She's a nurse practitioner. And I brought a plasma exchange to her and she's like, Oh yeah, I've been doing that for 10 years. And I told her what we would do it for. And she's like, Well, I've never done it for that. I've done it, but never for.

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