The Silent Fatty Liver Epidemic: Why Thin, Sober People Are Still at Risk
The Human Upgrade: Biohacking for Longevity & Performance
September 29, 2026
Fatty Liver, GLP-1s, Alcohol, Hormones, Brain Fog, Weight Gain & Longevity Host Dave Asprey sits down with Siggi Clavien, Founder and CEO of The Liver Clinic and de-liver-ance, to explore why the liver may be one of the most overlooked organs in metabolism, hormone health, detoxification, brain...
Speakers Siggi Clavien, Dave Asprey
TopicsHealth & FitnessEducationSelf-Improvement
Siggi Clavien (0:00)
The ability to lose weight goes down, because the liver metabolizes 70% of the fat we consume. If your liver is fatty, you gain weight quicker, and it's harder to get rid of weight. But 50% of people with fatty liver disease, which is 100 million Americans, are thin. About 80% of people with fatty liver disease, their blood panels are fine. That's why most people with fatty liver don't know they have it. The liver disease as a whole is up 500% in the last 50 years. So the same chemical that we use to cause liver disease in trials is what's used in dry cleaning, and you put that in your skin.
Dave Asprey (0:26)
What I'm doing to have a liver that reads like it's 10 years old in clinical scans. How many liver scans have you done so far?
Siggi Clavien (0:33)
Oh, well over 10,000, but we started to see most of the people's fatty liver reversing in three.
Dave Asprey (0:38)
Is there a drug that does that?
Siggi Clavien (0:39)
No, not even close.
Dave Asprey (0:42)
You're listening to The Human Upgrade with Dave Asprey.
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SPEAKER_3 (1:54)
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Dave Asprey (3:03)
This episode is all about the liver. And you could say, Dave, why are you talking about liver? Well, it's because I want to live to at least 180 and I think you do too.
And livers do a lot more than what we think about. There are primary detox organ, but even that doesn't really do it justice because of its role in metabolism, its role in longevity, aging, and so many diseases that we might think are the pancreas or the kidneys, but have a major role with the liver. So I'm going to teach you, well, what I'm doing to have a liver that reads like it's 10 years old in clinical scans, which is a good thing.
And our expert today is Siggi Clavien who runs Deliverance. He's an entrepreneur with a background actually in wine making in his family, who's gone really deep because of liver damage and liver disease in his family. And Deliverance is a supplement that has enormous amounts of clinical evidence, to the extent that many of the members of Unlimited.life, which is my concierge of VIP life extension medical practice, are taking because their lab results showed their liver was under stress. So we give them Deliverance and magically their livers get better. So Siggi is going to share some shocking statistics. We're going to talk about aging. We're going to talk about women. We're going to talk about estrogen and your liver and a strange connection between estrogen, alcohol and hormone replacement. So get ready, buckle in and tighten up your liver.
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