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The Peptide Secrets to a Youthful Face artwork

The Peptide Secrets to a Youthful Face

The Human Upgrade: Biohacking for Longevity & Performance

September 15, 2026

Carolina Reis de Oliveira on Reversing Skin Age, Menopause, GLP-1 Skin, and the Science of Senescent Cells Your skin is likely biologically older than you are, but new research suggests some of that aging may be reversible.

Speakers Dave Asprey, Carolina Reis de Oliveira

TopicsHealth & FitnessEducationSelf-Improvement

Dave Asprey (0:00)

Part of living to at least 180, or as long as you choose, is looking like yourself.

Carolina Reis de Oliveira (0:06)

There are studies showing that the skin just under or above your eyes are 25 to 30 years older than the skin on your cheek. As they go through menopause, their skin seems to be failing apart. They can't hold water anymore. Now with GLP-1, we are seeing so many people using our body lotion and really helping reducing the sagging and firming the skin through menopause. Women start to experience crepiness and the skin gets thinner.

Dave Asprey (0:33)

My massage therapist is like, well, your skin is changing.

Carolina Reis de Oliveira (0:36)

So we saw 93% of the participants seeing improvement in firmness and 97% seeing improvements in fine lines and wrinkles. And we compared it with Ropamycin, and Ropamycin was not able to reduce the biological age in a significant way. When we treated skins with ****, we saw a reduction in 2.5 years in the biological age of the skin. No one was doing this, you know, back in almost 10 years ago when we started this research. And we generated another 800 peptides, and we tested again, and then eventually found ****.

There is a low level of inflammation coming from your skin that's actually impacting your body. But if you can start using this as early as possible, you can prevent that loss of structure and declining collagen.

Dave Asprey (1:26)

You're listening to The Human Upgrade with Dave Asprey.

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Part of living to at least 180 or as long as you choose is looking like yourself, and that means taking care of your skin. Taking care of your skin is different for men and women, and it's different depending on how old you are chronologically and biologically. Some people have much younger skin, some people have older skin.

So how about we have a deep conversation with a PhD in stem cell biology and tissue engineering? Sounds like a good way to learn about skin, doesn't it? That's because our guest is the CEO and co-founder of OneSkin, a company that actually created a new peptide. Wait, can we say peptide without getting beat? We should probably bleep that one out depending on if we're on certain platforms. Anyway, a new series of amino acids that are stuck together to be a signaling molecule that shall not be called a bleep, because they're censoring people who talk about bleep. Now, I could be making a big deal of that, but I've been banned twice for very tame reporting of science on that, so I'm a little sensitive here. But it's funny, on X, they never seem to ban me for anything. It's kind of weird. So, co-inventor of five patents, published in multiple, multiple journals, and a person who's made a lot of the products that I use on my hair and on my skin, none other than Carolina Reis de Oliveira. Welcome back, Carolina.

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