Skip to content
The Best Singular Hack To Change EVERYTHING About Your Life artwork

The Best Singular Hack To Change EVERYTHING About Your Life

The Human Upgrade: Biohacking for Longevity & Performance

September 24, 2026

Back again with one of the best episodes we've done on the channel. So good that we had to play it once more for you! Today you’ll meet Robert Waldinger, M.D., who leads an extraordinary scientific study on happiness that’s still going strong after eight decades.

Speakers Dave Asprey, Robert Waldinger

TopicsHealth & FitnessEducationSelf-Improvement

Dave Asprey (0:00)

Have you hit your protein goal today? Well, you might, but it's probably not good protein. And ButcherBox has made it easier to get good protein for your protein goal. They deliver 100% grass-fed beef and organic chicken and wild-caught seafood and a bunch of other good stuff right to your door. They've already done the research and they made the tough sourcing decisions, so you don't have to go to the store and ask questions that the butcher can't answer anyway. That means all you have to do is decide what's for dinner. Every ButcherBox is customizable, so you can choose the cuts and the proteins that fit your routine and just what you like to eat. Busy weeknight or friends coming over? You've already got great protein ready to cook. My days are really busy, so it's easy to just throw one of their grass-fed steaks on the grill after I work out. And if you're looking for an easier way to make great meals, give ButcherBox a try. Go to butcherbox.com/humanupgrade to get $20 off your first box, plus your choice of free ribeye, New York strip, or filet mignon in every box for a year with free shipping always. Again, that's butcherbox.com/humanupgrade.

Be sure to use our link so they know we sent you. Why won't your stress budge no matter what you do? You're doing the work, the cold plunge, the breath work, the supplements, and your nervous system is still running hot. Here's the problem. Every recovery tool you use only works when your body believes the threat is over. And if your nervous system never gets that signal, it stays in survival mode regardless of what you stack on top of it. The direct line to that signal runs through your vagus nerve. When you stimulate it, your parasympathetic nervous system activates. Your body shifts out of fight or flight and into the state where real recovery happens. ZenBud is the tool I reach for to make that shift happen. It sits on your ears like a headset and uses focused ultrasound to reach your vagus nerve directly. Just five minutes daily is all you need. In clinical studies, participants experienced significant improvements across stress, mood, and sleep after just four weeks of use. Many people notice it in their first session. Check it out at zenbud.health and use code DAVE15 at checkout for a discount. Your biohacks are only as good as your nervous system's ability to recover. This is the missing piece.

You're listening to The Human Upgrade with Dave Asprey.

You're listening to The Human Upgrade with Dave Asprey.

This is a best of episode where I highlight and re-edit the most impactful episodes of the year for you to make sure that you see them. And if it's something that you heard the first time, this version of it is going to reinforce the most important learnings of the year. This episode is all about the fourth F word, which is friend. And if you're a longtime listener, you know that your body automatically in order says, is it something I'm afraid of? Fear. Is it something I can eat? Food. Is it something I can reproduce with? Fertility, which is an F word. And of course, friend, which is, is this something I form a community with. And since you're spending more time with loved ones over the holidays, this episode serves as a reminder of how relationships work because they affect your physical, your emotional, even your mental health. And the definition of biohacking, change the environment around you and inside of you, so you have full control of your own biology. The people around you are a huge part of your own biology. And this is why biohacking has always been for humans. It includes things that are specific for men or specific for women and specific for men and women in community because you can't have either one without the other. And we all interact via this fourth F word, friend.

Our guest, Dr. Robert Waldinger, MD., has led an extraordinary scientific study on happiness that's going strong after eight decades. Think about it. Back in 1938, the Harvard Study of Adult Development tracked two groups of men and their families with the goal of discovering what makes for a good life, what we would call health span. You could also call it thriving or happiness. They asked thousands of questions and hundreds of measurements were taken from brain scans to blood work. What they found out was loneliness can kill you because social connections are really good for you. It's the quality of your close relationships that matters, not the quantity. Good, close relationships don't just protect your body, they protect your brain. So what are you gonna get from this episode? You're gonna learn exactly the mechanisms by which relationships improve your physical, mental and emotional health.

63 more minutes of transcript below

Thousands of transcripts fetched by people building searchable podcast archives

Fetch the whole transcript

The demo key returns a sample episode in full, no card needed:

request
curl -H "x-api-key: pt_demo" \
  https://spoken.md/transcripts/1000651996090

Markdown with the speakers named, for your notes, your knowledge base, or anything that makes HTTP calls.

From $0.10 per transcript. No subscription. Credits never expire. Prices exclude VAT, added at checkout for EU customers. Not what you expected? Email us within 14 days with 20 or fewer credits used and we refund the pack in full.

Using your own key:

request
curl -H "x-api-key: YOUR_KEY" \
  https://spoken.md/transcripts/1000791427491