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Josh Duhamel on Nootropics, Peptides, and Testosterone at 53 artwork

Josh Duhamel on Nootropics, Peptides, and Testosterone at 53

The Human Upgrade: Biohacking for Longevity & Performance

September 16, 2026

At 53, Josh Duhamel says he feels better than he did in his 30s. Host Dave Asprey sits down with actor and Gatlan Health founder Josh Duhamel to talk testosterone, peptides, nootropics, brain health, fatherhood, and what it takes to stay strong as you age.

Speakers Josh Duhamel, Dave Asprey

TopicsHealth & FitnessEducationSelf-Improvement

Josh Duhamel (0:00)

I feel better now than I did in my early to mid 30s. I'm not even kidding you, my joints, my back, my knees. I just feel stronger because nobody's talking about it. Everybody's doing it. The agency that I'm no longer with, but they said, don't do it. It's bad for your image. Maybe I'm going to get made fun of in the town for having this company. And there's so many guys out there who would love this information.

Dave Asprey (0:20)

You're actually saving lives.

You're listening to The Human Upgrade with Dave Asprey.

Modafinil is one of my favorite cognitive enhancers forever, and I've been taking it for more than 20 years, which is why this episode is brought to you by Mod. Mod prescribes a once or twice daily Modafinil drink that can keep you energized, focused and alert throughout the day in a way you won't even believe. For the science nerds, here's how Modafinil works in my brain and probably yours. It's a wakefulness drug, not a stimulant that works on several systems in your brain. It activates something called Orexin, which is your brain chemical that helps to keep you awake, that isn't stimulant. Modafinil also increases dopamine, which is going to help you be motivated and focused. And it affects histamine and norepinephrine, which can help to keep you alert. Scientists figured this out in the 1970s when they developed Modafinil. And some of the highest performers on the planet, like me, have been using it since, well, about then. I only made it through Wharton Business School because I was taking Modafinil. You'll find soldiers, pilots, astronauts, even big figures in the government who are in high-stakes situations who use Modafinil because it actually works in many clinical trials. I've been talking about and using Modafinil for years. I broke the news about it on National News more than 15 years ago. And it's now available at mod.com to qualifying patients. Visit mod.com for a consultation. And you get 10% off your first order plus free shipping with promo code Dave. This is my favorite pharmaceutical performance enhancer on the planet. If it's appropriate for you, the doctors at mod.com can help you get it. See their website for important safety information. And thanks, Mod, for sponsoring the podcast. You really can't biohack your way around a broken gut because everything starts in your microbiome. It's tied to your immune system, your brain, your metabolism, even how well your body responds to everything you do. So your microbiome is off. Your supplements just deliver less energy, less of what you're paying for. And I have tried a lot of probiotics. Omnibiotic is one of my favorites, and I use it regularly. Most probiotics never make it past your stomach acid. And the top probiotic brands in the US average a 7% survivability rate. Omnibiotic reaches about an 83% survivability rate. That means when you take it, it actually gets where you want it to go. Probiotics aren't a one-size-fits-all. If you want better stress resilience or better recovery, detox support, better metabolic health, they make different formulas to get you different results. My favorite is Omnibiotic Hitox. Clinical studies show Hitox supports your liver function and improves cardio metabolic markers, lowers lipopolysaccharides. This is a toxin that gut bacteria make that is tied to aging and brain fog, something I have a particular problem with given my genetics. So that's why I love Omnibiotic. Find the formula that fits you at omnibioticlife.com. Use code Asprey 20% off your first order. I really like their formulas. Guys, doing breathwork here with Josh Duhamel, who's best known for his role in Netflix's Dawson Creek.

Josh Duhamel (3:16)

It's something like that, something like that.

Dave Asprey (3:19)

Ransom Kenyon.

Josh Duhamel (3:21)

Hey, I would have been stoked to be on Dawson's Creek back in the day. I auditioned for that show about 12 times, never got it.

Dave Asprey (3:28)

You did not? Yeah. Wow, okay.

I was just messing with you. I know. I once told the lead guitarist from STP, I'm like, oh, you're in Nickelback?

Josh Duhamel (3:39)

Just to see what he would say.

Dave Asprey (3:40)

He laughed his ass off. I love Nickelback, by the way. I think they're good.

Josh Duhamel (3:43)

I think Nickelback is awesome.

Dave Asprey (3:45)

They don't get the respect, but their music is legit.

Josh Duhamel (3:47)

They get disrespect.

Dave Asprey (3:49)

Yeah.

Josh Duhamel (3:50)

I don't get it. I like Nickelback.

Dave Asprey (3:51)

But it was still funny.

Josh Duhamel (3:52)

Yeah.

Dave Asprey (3:53)

All right.

Josh Duhamel (3:54)

I don't know if they're Stone Temple Pilots, but they're pretty damn good.

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