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The Longevity Playbook with Rhonda Patrick

StarTalk with Neil deGrasse Tyson

November 13, 2026

How do you live longer and better? Neil deGrasse Tyson and co-hosts Chuck Nice and Gary O’Reilly sit down with biomedical scientist Rhonda Patrick to explore healthspan, fad diets, and how to exercise for longevity.

Speakers Chuck Nice, Neil deGrasse Tyson, Gary O'Reilly, Rhonda Patrick

TopicsScienceEducation

Chuck Nice (0:00)

Every discovery starts with a question. What if? Why?

Neil deGrasse Tyson (0:04)

How?

Chuck Nice (0:04)

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Neil deGrasse Tyson (1:06)

Gary, however long I thought I was going to live, now I know I'm going to live longer. Following this advice about health, physiology, what you eat, how to exercise, what it's going to do to your brain.

Chuck Nice (1:15)

What supplements to take, what your diet should be and none of that matters if you have kids.

Gary O'Reilly (1:22)

And inflammation is good for you.

Neil deGrasse Tyson (1:24)

Find out why, coming right up, StarTalk Special Edition. Welcome to StarTalk, your place in the universe where science and pop culture collide. StarTalk begins right now.

This is StarTalk Special Edition, Neil deGrasse Tyson. You're a personal astrophysicist and if it's Special Edition, it means I got in the house Gary O'Reilly. Former soccer pro, soccer renouncer. And we, you're taking us, and the crowds cheer.

Chuck Nice (2:00)

I was just, you know, making them feel at home.

Rhonda Patrick (2:04)

A memory lane. He's just a little.

Chuck Nice (2:05)

He's the only guy that's used, in the room that's used to that.

Gary O'Reilly (2:09)

Maybe not so much applause, maybe abuse. If you want to throw some abuse, I'll feel more comfortable.

Neil deGrasse Tyson (2:14)

And we got Chuck Nice, the Lord of Nice.

Chuck Nice (2:16)

That's the way it's happening.

Neil deGrasse Tyson (2:16)

All right. So Gary, we're talking about living forever today.

Gary O'Reilly (2:21)

And spoiler, the show might take a while. Very nice.

Chuck Nice (2:26)

Well done.

Neil deGrasse Tyson (2:26)

So what do you have for us?

Gary O'Reilly (2:28)

Well, we've kind of talked about, as you've just alluded to, living forever. And we kind of hovered over it.

Neil deGrasse Tyson (2:34)

I didn't just allude to it. I said it.

Gary O'Reilly (2:35)

No, I know. So we've kind of touched on that from time to time, and that means increasing your lifespan.

Chuck Nice (2:42)

First, you got to get a billion dollars, remember. That's rule one.

First, you get a billion dollars, then you want to live forever.

Neil deGrasse Tyson (2:48)

Oh.

Chuck Nice (2:49)

Funny how that works.

Gary O'Reilly (2:51)

So you can spend it.

Rhonda Patrick (2:52)

Right, yeah.

Gary O'Reilly (2:53)

But there's a new kid in town.

Neil deGrasse Tyson (2:55)

What's that?

Gary O'Reilly (2:56)

Healthspan.

Chuck Nice (2:57)

Healthspan.

Rhonda Patrick (2:59)

Yes.

Neil deGrasse Tyson (3:00)

Healthspan.

Gary O'Reilly (3:01)

Today, we're going to learn what will and will not stretch out your healthy years.

Rhonda Patrick (3:06)

I like that.

Gary O'Reilly (3:07)

Right, so I'm going to leave it hanging just there. So Neil, if you would introduce our guest.

Neil deGrasse Tyson (3:10)

Oh, sure. We have Dr. Rhonda Patrick. Rhonda, welcome to StarTalk.

Rhonda Patrick (3:16)

So excited to be here.

Neil deGrasse Tyson (3:18)

Excellent. And you came in from where this morning?

Rhonda Patrick (3:20)

California. California. All right.

Neil deGrasse Tyson (3:23)

You are a PhD biomedical scientist. What was your PhD topic or subject?

Rhonda Patrick (3:30)

Cancer metabolism.

Chuck Nice (3:31)

Oh.

Rhonda Patrick (3:33)

How cancer cells hijack our metabolism. They hijack everything.

Neil deGrasse Tyson (3:38)

Yeah, I know. Oh my gosh.

Chuck Nice (3:39)

Actually, too bad we're not made of cancer. We would live forever.

That's a weird soul.

Rhonda Patrick (3:47)

Yeah. Or if we're some virus.

Neil deGrasse Tyson (3:49)

Or virus that just hijacks whatever and just keep going.

Rhonda Patrick (3:51)

I'm serious. I mean, it's true. These cancer cells can be immortal until they take down the host that is hosting them. Yeah.

Neil deGrasse Tyson (3:58)

So they can't be too effective.

SPEAKER_5 (4:00)

Otherwise, they kill their host.

Neil deGrasse Tyson (4:02)

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