The Great Peptide Debate, SpaceX's Lunar Mass Driver, AI Coming for Zuck's Job | Martin Shkreli & Max Marchione, Mitchell Green, Shane Hegde, Dr. Adam Oskowitz, Robin Vince, David Senra artwork

The Great Peptide Debate, SpaceX's Lunar Mass Driver, AI Coming for Zuck's Job | Martin Shkreli & Max Marchione, Mitchell Green, Shane Hegde, Dr. Adam Oskowitz, Robin Vince, David Senra

TBPN

March 23, 2026

Sign up for TBPN’s daily newsletter at TBPN.com (01:22) - SpaceX's Lunar Mass Driver (41:12) - 𝕏 Timeline Reactions (54:37) - AI Coming for Zuck's Job (58:17) - The Great Peptide Debate w/ Martin Shkreli & Max Marchione.
Speakers: John Coogan, Jordi Hays, Tyler, Martin Shkreli, Max Marchione, Mitchell Green, David Senra, Shane Hegde
**John Coogan** (0:00)
You're watching TBPN. Today is Monday, March 23rd, 2026 We are live from the TBPN Ultradome, the Temple of Technology, the Fortress of Finance, the capital of capital. Let me tell you about ramp.com. Time is money, save both, use corporate cards, bill pay, accounting and a whole lot more, all in one place. I think you got the whole following.

**Jordi Hays** (0:20)
Very barnyard-themed this morning.

**John Coogan** (0:22)
Very barnyard-themed. Let me pull up the linear line up. Linear, of course, is the system for modern software development, and 70% of enterprise workspaces are using agents if they're on carrier.

**Jordi Hays** (0:32)
Very fun day today. We got Martin Shkreli coming on with Max over at Superpower to debate peptides, two very different stances on these compounds. Now, we will see how it goes.

**John Coogan** (0:48)
Bring the popcorn. Is there a peptide that helps with debating?

**Jordi Hays** (0:53)
I'm sure there is.

**John Coogan** (0:54)
Is there like a dbt1, dbt157 that you can take and then you become a credibly big debater?

**Jordi Hays** (1:00)
Hopefully, Max can make one before...

**John Coogan** (1:03)
We'll see. Then we have Mitchell Green, Lead Edge Capital coming on, 1230 Shane from AIR, we're going into a lightning round. And then David Senra is coming on at 115, hanging out in person.

**Jordi Hays** (1:15)
Don't forget, we're going to ask Robin from BNY and Matt from Doctronic.

**John Coogan** (1:20)
Yeah.

**Jordi Hays** (1:20)
It's a very fun day.

**John Coogan** (1:21)
Anyway, over the weekend, you watched this live, right? Elon Musk, the CEO of Tesla, the CEO of SpaceX, got some folks together, gave a big keynote presentation about his vision for the future.

**Jordi Hays** (1:36)
Basically something that looked like an ultradome.

**John Coogan** (1:38)
It did look like an ultradome. And so you watched this, right?

**Jordi Hays** (1:41)
I did watch it.

**John Coogan** (1:42)
I watched a little bit of it and overall...

**Jordi Hays** (1:45)
And if you were taking a shot every time Elon said, epic, you were not in any state to drive after about three minutes.

**John Coogan** (1:55)
Yeah. He's got so much going on at this point. I mean, he's doing sports cars, cyber trucks, Model 3, Model Y, just consumer cars.

**Jordi Hays** (2:06)
YXL.

**John Coogan** (2:08)
Space Internet, space data centers, space launch capacity, point to point. He's going to take us from one on a rocket from New York to Tokyo in an hour, 30 minutes. Neuralink brain chips, tunnels. These Elon projects have just gotten bigger and bigger and bigger. Of course, he owns X and Twitter. XAI, training foundation models, trying to make a consumer app. We chat with it as well as solve math and physics.

**Jordi Hays** (2:39)
This was super rough.

**John Coogan** (2:41)
I listened to it and it was a rough delivery.
He seemed a little like, just like, okay, I got another thing to present. So the cadence wasn't quite there and he wasn't able to get the crowd going. There was a lot of waiting a little bit for the audience to realize that was a pause line.

**Jordi Hays** (2:58)
Key disclaimer, never bet against Elon.

**John Coogan** (3:01)
True.

**Jordi Hays** (3:01)
I'm not dumb enough to bet against Elon.

**John Coogan** (3:03)
Yes.

**Jordi Hays** (3:04)
I'm not dumb enough to try to short any of his company. Yes, for sure. And I'm not, you know, by now you should have learned not to doubt what his organizations can do.

**John Coogan** (3:18)
Yeah.

**Jordi Hays** (3:19)
And even though this Tarifab concept, you know, there's a lot of reasons that you would want to bet against it.

**John Coogan** (3:24)
Yep.

**Jordi Hays** (3:25)
There's a lot of, I don't know that many people that are genuinely sold on the space data centers in the near term. It's still, it's not clocking for me, John.

**John Coogan** (3:38)
It's not clocking for me. That he's standing on business?

**Jordi Hays** (3:41)
It's not clocking.

**John Coogan** (3:42)
He's standing on business and you're, it's not clocking for you.

**Jordi Hays** (3:44)
It's not clocking to me that he's standing on space data centers. And so this entire pitch, you know, is notable, seemingly the first time he's put the Tesla XAI SpaceX logos together.

**John Coogan** (3:59)
Sure. No, the Tunnel Project Hyperloop was a blog post that he wrote and it appeared both on the Tesla blog and the SpaceX blog at the same time. And everyone was like, who's going to be involved in this? And it turned out it was like a couple people from both sides. It became its own company at some point.

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