Most Replayed Moment: The First Warning Signs Of Insulin Resistance! Check Your Skin For This

**Steven Bartlett** (0:04)
So, when I'm, you're 54 years old, when I'm 54 years old, I want to be as young and energetic and articulate and cognitively astute as you are. So, what should I be doing now to make sure that I don't decline decay in all those areas I described?

**Annette Bosworth** (0:21)
Well, what do you have for breakfast?

**Steven Bartlett** (0:23)
Today?

**Annette Bosworth** (0:24)
Yeah.

**Steven Bartlett** (0:25)
I have not eaten breakfast yet.

**Annette Bosworth** (0:27)
It's okay. That's not a bad thing. But when you're 54, you should probably put the calories in the morning, not at night. We know that as you age, the cost of a calorie turns into timing. If you eat that one bite of food after six o'clock, it's worth 10 bites of food before noon.
So, if you're trying to say, how do I get the best out of the nourishment, but also eating is fun, if you only get one bite after six o'clock and 10 before, move that food towards morning. When you're your age, what's the last meal you ate?

**Steven Bartlett** (1:03)
Yesterday? Yeah.
For dinner, I had this cod and I had salad. I also had pasta.

**Annette Bosworth** (1:11)
Okay.

**Steven Bartlett** (1:12)
But I ate pretty late, which is about the same.

**Annette Bosworth** (1:13)
What did you have the rest of the day before that? Was that your first meal?

**Steven Bartlett** (1:16)
Just a big salad.

**Annette Bosworth** (1:18)
Was that more towards lunch or noon?

**Steven Bartlett** (1:21)
Probably about four o'clock.

**Annette Bosworth** (1:22)
So, waited all the way to four o'clock to eat. Very common. This is a really common pattern of people doing what we would say intermittent or time-restricted eating. They put that eating window in this, but it's got that balloon at the end of the day.

**Steven Bartlett** (1:33)
Yeah.

**Annette Bosworth** (1:33)
And it really does. I mean, what you're stimulating is an excessive production of insulin. And you're going to wake up the next morning. What time did you wake up this morning?

**Steven Bartlett** (1:43)
Today? I went to bed fairly, relatively early for me. I woke up at about 7:30 a.m. Usually, it's later.

**Annette Bosworth** (1:50)
And did you have a solid seven, eight hours of sleep or how?

**Steven Bartlett** (1:54)
Yeah.

**Annette Bosworth** (1:55)
So during that time, you finished eating around 10 o'clock, then it sounds like?

**Steven Bartlett** (1:59)
Yeah.

**Annette Bosworth** (1:59)
Okay. So then it's 7

**Steven Bartlett** (2:00)
Maybe a bit later.

**Annette Bosworth** (2:01)
Okay. So 11 o'clock and you've got 7.3 in the morning is when you woke up, so that's about eight hours since you've eaten.
Your insulin is still churning, especially if the meal was large and there was carbs in it. So now you've got these processed foods late at night, and you're at the beginning of the disease, right? You're at the beginning of the chronic inflammatory turn of how do you age faster and faster? You don't do that. You don't have high insulin throughout the night.

**Steven Bartlett** (2:26)
So can you explain to me, like I'm a 12-year-old, what insulin is and the role it's playing? Because I guess we're focused here on how to, I guess, longevity, aging for a second. But how does insulin play a role in all of this and what is insulin?

**Annette Bosworth** (2:40)
So insulin insulates. Okay. So think of it as it makes you fluffy.
It puts the fat on.
It's got some other roles too. But we're going to talk about chronic diseases here where it's not a scarcity problem. You make plenty of it. And when it's in excess, it will store energy for when you go through a famine. It will also cause you to grow. Now, grow means get a little fatter, but it also means things like their skin gets a little thicker, they have skin tags. And what I always think about is what's going on in their brain. And when that insulin is high for years and years and years, just like yours, because if you didn't eat the rest of today, and then you got up tomorrow morning, it would be about that long after a late meal last night. That's how long it would take you to say, okay, we're back down to where we started from or where we should be in the morning.

**Steven Bartlett** (3:36)
For someone that's never heard the word insulin before, there's some context to give in terms of what it's doing. So it's coming out like a transporter and helping put away the sugar, or deal with the excess sugar.

**Annette Bosworth** (3:46)
Right. So it is what lifts glucose or sugar from the circulation into a cell. That's its first primary job. But if all the cells are full, their storage is full, it's going to start to pack it into the liver. Let's say all those stores are full too. This job of insulin, this hormone, oozes into every part of your body to say, make sure it's got fuel, make sure it's got that sugar.