Matt McCusker, Andrew Huberman & Tom Segura - Mostly Wise #1 - #1102

**Chris Williamson** (0:00)
I keep seeing tweets about how everyone should be taking erectile dysfunction medication. Is that true?

**Matt McCusker** (0:04)
Low-grade, whatever, yeah, like low-grade.

**Andrew Huberman** (0:07)
So, Tadalafil, which is the generic name for Cialis, was developed first as a prostate health drug. And then people took more of it and realized that at higher dosages, it can be effective for erectile dysfunction.

**Tom Segura** (0:20)
But low dose is good for prostate health.

**Andrew Huberman** (0:22)
Low dose, like 2.5 to 5 milligrams per day, is very helpful for perfusion of the prostate. And also, it causes vasodilation in the brain. So, things like strokes, I mean, you want blood flow, right? You don't want excessive blood flow, but you've got a headache from it. But our chair of male sexual health and urology at Stanford, Mike Eisenberg, he came on the podcast and he said, pretty much every male over 40 or so should be taking about 2.5 to 5 milligrams per day.

**Matt McCusker** (0:49)
Does it still get you pretty hard, too?

**Andrew Huberman** (0:50)
It definitely will improve. She's curious.
It will definitely notch up erectile, strength, but unlike some health people out there, I'm not using the calipers to measure the strength. I asked someone else to measure, and she tells me that it's all good.

**Matt McCusker** (1:15)
I know what you mean. You should tell her to close her hand if she can.

**Andrew Huberman** (1:18)
Well, no, I've never actually subjected to the grip test.
I don't want to tempt anybody. But in all seriousness, this drug that was developed for vasodilation, which is now used for erectile dysfunction, it really was developed first as a prostate health drug. A lot of sitting, the prostate is weird too, because it doesn't get a lot of blood flow compared to other tissues. Speak for yourself. Same immune system.

**Matt McCusker** (1:43)
What if you sit with a plug?

**Andrew Huberman** (1:45)
You're kegaling all day.
We realized Chris had to pull up to this little piece of tape, so we didn't catch him kegaling over the desk. Kegaling, kegaling.

**Chris Williamson** (1:54)
I kind of feel like it could just be a psyop to normalize erectile dysfunction medication by dudes that have got erectile dysfunction. By doing that, every man should be taking it, that nobody is then on the outside.

**Tom Segura** (2:05)
It's fair. I take the six, it's like five to six milligrams in the morning.

**Andrew Huberman** (2:10)
You do it in the morning?

**Tom Segura** (2:11)
Yeah, every morning.

**Chris Williamson** (2:13)
What's a little mint? Is that half? What's like a-

**Andrew Huberman** (2:17)
Oh, I don't know. I mean, you can get-

**Chris Williamson** (2:19)
Is that a full one or a half one?

**Tom Segura** (2:20)
Of what?

**Chris Williamson** (2:21)
The Tadolophil.

**Tom Segura** (2:22)
Well, I'm saying it depends on the prescription that you're given.
The six milligram thing is supposed to be for prostate health. But if you were to get 25, 50, obviously that's like massive blood flow and you're going to take note.

**Andrew Huberman** (2:38)
It can draw blood.

**Chris Williamson** (2:40)
Strong gust of wind.

**Andrew Huberman** (2:41)
Yeah. It can disrupt, lower blood pressure slightly and things like that, because you're getting vasodilation, so all the pipes are getting a little bigger.

**Tom Segura** (2:50)
But let's all take one right now and see how the podcast goes.

**Chris Williamson** (2:53)
Whoever gets the erection last wins.

**Andrew Huberman** (2:54)
Yeah.

**Tom Segura** (2:56)
I have a strong mind.

**Andrew Huberman** (2:59)
This is not the podcast I signed up for.
But to your point, it probably does feel safer for guys to call up their doctor and go, hey, I heard this podcast. I heard some MD. Ph.D. from Stanford, not me, but Mike Eisenberg said that I should be getting better perfusion in my prostate. I should take 2.5 to 5 milligrams of Tadalfil. And there they just avoided all the statements about C. Alice, ED, da da da, da da da. And then they call another doctor and get a duplicate prescription and now they're taking double. You can assume that some of that happens, but it's also cost like pennies. It's generic now, the patent is out.

**Chris Williamson** (3:35)
Do you know the story about how Viagra was found?

**Andrew Huberman** (3:38)
I only know that it was very quick to market. It's one of these like remarkable discovery to suddenly like it was on the market. And that just tells you how badly certain people wanted on market and to use it.

**Chris Williamson** (3:51)
The story was that they were trying to do something, I think it was for angina, it was more hot stuff. And they found typically when medical trials finished and they asked people to give the medication back, people don't have any issue in doing it. And no one wanted to give the medication back.