Episode 909: Martin Shkreli Tries To Save Degenerate Biotech Gambler From Losing His Money artwork

Episode 909: Martin Shkreli Tries To Save Degenerate Biotech Gambler From Losing His Money

The Shkreli Pill

July 28, 2026

In this episode, Martin speaks with a biotech trader about his high-risk approach to investing and the positions putting his portfolio at risk.
Speakers: Martin Shkreli
**Martin Shkreli** (0:00)
Yeah, goodie, goodbye, you'll learn. It's pretty simple stuff. Average, that average lifespan thing is very volatile. There's a lot of average that has changed. The average is no longer the average. Happens all the time, 20 years of this. The length of a clinical trial has almost no bearing on anything. You will see. Just don't bet your life savings. That's all I suggest. I want you to make your bet. I want you to have fun, but don't bet everything. Because you may learn a little bit more about clinical trials than you knew before.
Yeah, yeah, yeah, you'll see.
Patience can live a year, man. There's absolutely no reason. I've done this my whole life. I'll look at it at some point before I drop my short report. You'll see how it works. You can't even spell the word coherent, so I'm telling you what the answer is. You're just not picking it up. The overall survival for those patients have improved dramatically since you last measured what you think they should be doing.
Okay. So the AML patients are living for five years, so wonderful. You must think it's a miracle. A cancer vaccine. You're bullish on a cancer vaccine. Yeesh. Just don't, just don't go all in, like I said, you know, make your bet. There's nothing wrong with that. That's the thing. Goodbye terrain. Again, with experience, experience is a good thing. You learn that the standards are always improving. I remember with Oncothyrion and with Cardiff just recently, you know, looking at the old, old data. I mean, I can guarantee you this trial will fail. I will change my name. I will turn into a trans. Whatever you want me to do, this trial is going to fail. And I will write that on Twitter, but I'm going to write it with my short report.
Yeah, we'll see. Well, no soon, right? I mean, you make your bet, I'll make mine, and we'll see soon. Standards are always improving.
Yeah, I'm not going to change my name to your name. I mean, I don't even know who you are. You're just some piker. But I will turn trans just for you.
I'll shave my head. I don't know when I'm releasing my short report. Do I have time to release it? Do I know anything about relapsed AML? My man, I've been doing this 20 years. Yes, the answer is yes, I do. Are these flit three naïve patients, by the way, or flit three wild type? Do you know?
Well, I'll start with flit three.
Yeah, I never I'll move to Haiti.
Change my name.
Do we know if that's a Flit 3 wild type, you guys know?
Yeah, I mean, listen, if you think a miracle is going to happen, and the drug works, you know, you should buy it. I think the drug doesn't do anything. I actually think best alternative might beat the drug arm.
You're saying FLiT3 doesn't make it to CR2? I'm not so sure.
I mean, I wouldn't even use the word drug for what this thing is. I wouldn't even call it a drug. And again, you never say never. It's one thing Capricor taught me. I kind of outsourced my due diligence in Capricor, unfortunately, but I mean, I believed in it. I'm not saying I didn't believe in it. I should have really... The right way to do a binary event is you eat, sleep, and breathe it. That's the only real... The best way to do it.
Look, I just, you know, if you know pharmacology, it's pretty obvious this drug can't work. Amyl is a vicious disease. It's... This ain't gonna cut the cheese. But again, you know, make your bet. All I'm saying is don't put your life savings on it. Take something off the table. You know, Dusty believes in it. You know, if you believe in it, that's fine. Just, you know, don't do the stupid thing, which is to go all in. I'm not gonna go all in.
Just only lose the money. Only be willing to lose the money you can afford to lose. That's a very uncertain, you know, thing, biotech. I've only been trading it for 26 years.
Did they try it in different indications? I didn't know that. I haven't looked at this in a while. I just remember looking at it for dusty, and I was very convinced. It had all the telltale signs of a failure in the making. Just because the stock price has gone up doesn't mean shit.
I just think, you know, again, if you've been around the block, you know that increased survival doesn't really... Companies misestimate this stuff wildly all the time.

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