Episode 575: Dr. Jonathan Schoeff: Peptides and the Marketing Behind Modern Longevity - Part 2

**Dr. Jonathan Schoeff** (0:01)
Hi, guys, it's Tony Robbins. You're listening to Habits and Hustle. Crush it.

**Jen Cohen** (0:08)
Welcome to the Habits and Hustle podcast, where I sit down with the world's biggest thinkers, entrepreneurs, athletes, and experts to uncover the habits, strategies, and mindset shifts that actually move the needle in your health, happiness, and success. And today, I'm back with Dr. Jonathan Schoeff, a surgeon, longevity expert, and co-founder of The Longevity Lab, who is still very actively practicing medicine, I should say. After part one, we knew there was way too much leftover that we had to keep on going. So in this part of the conversation, we get into this stuff everyone is talking about, but very few people actually understand, which is GLP-1s, muscle loss, fasting, testosterone, biomarkers, grip strength, movement, sleep, longevity metrics, which are actually worth paying attention to. What I love about Dr. Jonathan is that he does not make health more complicated to sound smart. He breaks it down in a way that makes you question the trend, understand the mechanism, and come back to the basics that actually moves the needle. What he shares in this episode will change the way you think about GLP-1s, fasting, muscle, and health markers that you should actually be tracking.
Let's dive in. Enjoy.
Yeah, no matter what.

**Dr. Jonathan Schoeff** (1:34)
Then you can-

**Jen Cohen** (1:35)
Are they all skin better that you like?

**Dr. Jonathan Schoeff** (1:36)
I do like the skin better formulations. I know it's goofy.

**Jen Cohen** (1:41)
Why is it goofy? It's not goofy.

**Dr. Jonathan Schoeff** (1:43)
Well, because as a guy-

**Jen Cohen** (1:44)
As a guy, yeah. Well, you're like very, you take care of yourself.

**Dr. Jonathan Schoeff** (1:49)
Well, I'm taking care of. That's how it works.

**Jen Cohen** (1:52)
Okay. Well, either way- I do what I'm told. You don't-

**Dr. Jonathan Schoeff** (1:54)
Okay, listen.

**Jen Cohen** (1:54)
I do what I'm told. Well, it's working. Okay. Now, looking into the GLP-1 stuff. Okay. Let's do it. So you said that reticulotide is-
Are you on any of these GLPs?

**Dr. Jonathan Schoeff** (2:03)
Life-changing. No. I've used all of them.

**Jen Cohen** (2:05)
You have used all of them.

**Dr. Jonathan Schoeff** (2:07)
Absolutely.
Well, simaglutide and up. So simaglutide, trisepidide, reticulotide. I've used all of them.

**Jen Cohen** (2:13)
So if people are having like- So between trisepidide and reticulotide, I know one works on two receptors, one works on three receptors.
So you believe it's a tool, and you don't believe everyone should be on them, even though you're talking about the insulin resistance to build muscle. So here comes the contradiction, right?

**Dr. Jonathan Schoeff** (2:31)
Totally.

**Jen Cohen** (2:32)
So if muscle is the biggest longevity organ to keep your insulin low, yet GLP1s have been obviously known to break down muscle and eat away at your muscle.

**Dr. Jonathan Schoeff** (2:43)
They've been blamed. They've been alleged.

**Jen Cohen** (2:46)
Alleged.
Yes. So you don't think that the GLP1s...

**Dr. Jonathan Schoeff** (2:50)
It's not that simple. No.
Well, I mean, I know the data. Okay. So if you look at step one trial, which was the first semaglutide weight loss trial 2021

**Jen Cohen** (3:00)
Okay.

**Dr. Jonathan Schoeff** (3:00)
What did it demonstrate? This is really important. 40 percent loss of lean body mass, LBM. So the problem is, and I just saw a post on this just the other day, lean body mass is not skeletal muscle. They're not the same thing. 40 percent is lean body mass. So if you want to make the argument or say you're a personal trainer, you want to get your hustle or you want to do some peptides, this and the other, then you say, oh my gosh, 40 percent loss of skeletal muscle. No, it's lean body mass. And realize that lean body mass includes skeletal muscle as one component. In healthy fit individuals, that may reach the 50 percent mark. In other words, 50 percent of your lean body mass in a very fit, well-muscled individual can be skeletal muscle. That's in a really fit person. Yeah. So it goes down from there. In other words, no one lost 40 percent of their muscle. That's not reality. So it's lean tissue. So it's lose fat mass, but it also includes organ mass. So non-alcoholic fatty liver disease, which is what read of True Tide, 100 percent reduced their fatty liver, which is that's a game changer from a health perspective. In that case, that's a part of lean body mass. So improving the metabolic function of your liver, losing liver fat is a very good thing, and that's lean body mass too.