David Sinclair (Harvard Professor) Reveals Age-Reversing Science to Look & Feel Younger

**Peter Diamandis** (0:00)
Have we reached some state of age-reversible technology that truly works?

**David Sinclair** (0:05)
We can cure diseases and injuries that have never been cured before. And so imagine in 10 years, you just take a pill for four weeks and you get younger.

**Peter Diamandis** (0:15)
Why do we age?

**David Sinclair** (0:17)
The epigenome is the issue because going through sperm and egg and fertilization resets the epigenome. But the good news is we figured out a way to safely reset that without having to clone yourself. We've gone from the idea that, oh, we just take a supplement or we do some exercise to slow down aging. Now, we're talking about the ability to truly reset the body, reset all of the cells in the body to be young again. Teenager today will live into the 22nd century.

**Peter Diamandis** (0:47)
Now, that's the Moonshot, ladies and gentlemen. Welcome to Moonshots, everybody. Today's episode is delivering on a State of the Union on Age Reversal, focusing on one of my favorite Moonshots, Longevity. We'll be discussing epigenetic reprogramming, when we might reach longevity escape velocity, and the role of AI in our longevity quest. My guest here is a dear friend, a brilliant scientist, Dr. David Sinclair, professor at Harvard Medical School, author of Lifespan, one of my favorite books. We'll talk about what comes next from David's authorship and one of the leading thinkers in the realm of age reversal, epigenetics and longevity science. We'll discuss what's here on the near term, how you can support it, how you can be involved in it, how you can benefit from it. We'll also discuss why at age 55, David looks like he's 35 I believe we're living during the most extraordinary times in human history, and if you want to see more of this future, if you want additional decades in your life, this is the episode for you. Alright, let's jump in with Dr. David Sinclair and a whole download on the state of age reversal. David, welcome buddy.

**David Sinclair** (2:01)
Hey Peter, it's good to be back.

**Peter Diamandis** (2:02)
It's good to have you back.

**David Sinclair** (2:03)
How are you doing?

**Peter Diamandis** (2:04)
I'm doing well, you know, I'm having a blast. I am more focused on my health than I ever have been.

**David Sinclair** (2:11)
You're looking really good. I was commenting on your biceps right now. That's why I'm wearing a jacket here, because I don't have them.

**Peter Diamandis** (2:18)
I think, and we can talk about this, that in fact muscle mass and exercise still remains one of the primary pro-longevity drugs out there.

**David Sinclair** (2:27)
Absolutely, yeah.

**Peter Diamandis** (2:28)
And we'll get into the details of what the best day of the art is and what's coming because eating right, sleep, diet, all of these things can only get you so far. And then the question is, can we turn back the clock of time? So here's my opener for you. It's 10 years from now. It's 2035 Have we reached some state of age reversal technology that truly works?
How well does it work? How often are you taking this treatment? And what does it cost? Give me a vision of the future here. Right. Well, I'm not asking for promises, I'm asking for your best guess.

**David Sinclair** (3:13)
Yeah, sure. I'm not shy to talk about what I think is coming.
And as I wrote in my book Lifespan, I predicted a future where we would have wearables and we would have video conferences with our doctors and you could order medicines online. And I thought that was going to take 15 years and it happened in three. And so sometimes I'm actually, I underestimate what we're actually looking at. So here's what I see. So I sit on the front row of the future, right, for this longevity.

**Peter Diamandis** (3:42)
The bleeding edge, I would say.

**David Sinclair** (3:44)
Yeah. And so I want to share my thoughts. With the listeners, what I'm seeing in my lab and labs that are competing with us or collaborating with us is something quite remarkable.
And the pace of change is making my head spin off. And I'm an optimist, but I just can't comprehend right now how fast things are going. So let's just go back a few years and then we'll project into the future. Going back a few years. So 2017, it was just a theory that we could reverse aging. Even the word reverse, and still to some extent, is apparent to my colleagues. But we actually we proved that, and published in 2020, that you can reverse most aspects of aging by reprogramming cells, which we'll talk about. And that changes everything. If my information theory of aging is correct, which is, we'll talk about the idea that you don't just lose information as you get older, like software corruption, you can actually reset that.