Claude Opus 4.5, White House "Genesis Mission" & Amazon's $50B AI Push w/ Emad Mostaque, Salim Ismail, Dave Blundin & Alexander Wissner-Gross | EP #211

Alexander Wissner-Gross (0:00)

I've compared this moment to 1939 This is the Manhattan Project.

SPEAKER_2 (0:04)

Similar to the Apollo Project that put a man on the moon in 1969 This is an all-in national effort to take the power of AI, to use the world's largest supercomputers to advance innovation and science.

Peter Diamandis (0:19)

This is just extraordinary. I think this could be the greatest accelerator for human knowledge in the US yet, if it's properly funded and executed.

Emad Mostaque (0:28)

Genesis 1 is, you know, God created the heavens and the earth. Finally, we have the tools to actually be able to understand them properly. Application of large amounts of compute with the reagents allows us to unravel the mysteries of the earth and the universe.

Salim Ismail (0:40)

You know, if we went back to the beginning of the year, did we predict that we'd be here or is it moving faster than even the few of us could predict?

Peter Diamandis (0:54)

Now, that's the Moonshot, ladies and gentlemen.

Hey, guys, welcome to our emergency pod for Thanksgiving week. A lot going on here, Genesis Mission. We're going to be talking about that. We'll talk about Anthropix, U, Claude 4.5. I'm here with AWG, Mr. EXO. And thank you, Emad, for joining us. I know this is Thanksgiving for you in England as well, isn't it?

Salim Ismail (1:20)

It's Thanksgiving for everyone.

Peter Diamandis (1:22)

Aha, yes, for sure. So I wanted to start with a question, which is what does Thanksgiving look like in the year 2035? I'm curious, is it going to change at all? Salim, you want to kick it off? Is 2035 far enough away to make a difference?

Salim Ismail (1:38)

It's a hell of a difference. I mean, look, by that point, we should have the cost of Thanksgiving dinner dropping by 10x. It should be personalized to you for your nutrition. So that depending on your metabolism, the turkey or ham or whatever the heck it is, is totally customized to the ability. I'll have a little device inside me saying, whoa, whoa, whoa, before you eat that turkey, I'm still metabolizing the cauliflower. Give me three minutes, please take a sip. Do not drink alcohol quite yet. Da, da, da, da, da. And I think we'll have, we should have gotten to the point over this hump of kind of expensive energy that we have ultra cheap energy, ultra cheap food, and we're crossing right into the Alex Rubicon.

Peter Diamandis (2:25)

All right, all right. My addition is we'll have Tesla bots serving us everything.

How about you, Alex?

Alexander Wissner-Gross (2:35)

Yeah, I think if we're not celebrating at least some subset of humanity is not celebrating Thanksgiving on Mars. Some subset is celebrating Thanksgiving in the cloud in the form of uploaded humans. And maybe we have some uplifted non-human animals also celebrating with us at the table, then something's gone terribly wrong over the next few months.

Peter Diamandis (2:56)

So I get this. So we're going to have uplifted turkeys arguing with their lawyers to keep a ceasefire against killing them all.

Alexander Wissner-Gross (3:04)

Yeah, if that doesn't happen, then something's gone wrong over these 10 years.

Peter Diamandis (3:07)

Emad, how about you? What are you going to see in 10 years time?

Emad Mostaque (3:10)

Yeah, I mean, 10 years is the pessimistic end of the AGI forecast, right? So assuming that humans don't end up like turkeys, we get happier, happier and then AGI, it goes straight down. Well, we'll figure out how to do perfectly moist turkey by then. But then as Alex has said, mathematics should be solved by then, science, etc. So you're in the post-abundance world, hopefully, with the robots and more. And there should be a lot to be thankful about if we can navigate what's coming.

Peter Diamandis (3:39)

Yeah, if we can navigate what's coming. OK, well, we're going to talk about that. But before we do, I want to jump into our first story, which is a doozy. Let's hear and learn about the Genesis mission coming out of the White House. Very powerful concept. All right, let's dive into this with a video.

SPEAKER_7 (4:03)

In every age, humanity invents new ways to see further. The telescope let us glimpse the stars. The microscope revealed the worlds within us.

For centuries, thinkers like Leibniz, Shannon and Turing dreamed of making all knowledge computable. But today, knowledge grows faster than our ability to understand it. Trillions of data points, a universe of information still unconnected. Now, a new instrument emerges. One capable not only of observing the universe, but of understanding it. Genesis Mission will transform how science is done in America, uniting our brightest minds, most powerful computers, and vast scientific data into one living system for discovery. Built on artificial intelligence and quantum computing, it will radically redefine the scale, speed, and purpose of scientific progress in America. This is the work that will define our generation's legacy. A new revolution begins. One guided not by competition alone, but by curiosity, imagination, and the belief that discovery is the truest form of progress.