Best Peptides, Stem Cells, Testosterone & Exercise Hacks - Biohacking Roundtable - #1148
Modern Wisdom
September 10, 2026
In this Biohacking Roundtable, we explore: What the best peptides for health & muscle building are. The latest biohacking tech that is real but sounds like science fiction. Which longevity supplements offer the most bang for your buck & are worth your time.
Speakers Chris Williamson, Ben Greenfield, Brigham Buhler, Dr. Gabrielle Lyon
TopicsSociety & CultureHealth & Fitness
Chris Williamson (0:00)
People of the UK and Ireland, if you are coming to see me on tour, I want to hear from you. I want to know what problems you're dealing with, your worst first date, and any questions that you've got for me. And I will be bringing some of you up on stage to talk about it. So if you're coming to see me on tour this October, go to chriswilliamson.live slash stories, submit them, and I might see you with a mic in front of your face very soon. Chris Williamson dot live slash stories.
Everyone, tell me what peptides you're on. That's all I care about.
Ben Greenfield (0:26)
Let's go. Which day of the week? Which time of the day?
I view peptides as a little bit more of like a condiment that's in your refrigerator that you might use for a specific reason and don't follow an exact protocol every day. For example, when I travel, I use thymus and alpha 1, which I'm on right now, as you can tell, for the immune system. Yeah. I keep around BPC 157 and TB 500 for injuries. I run a couple of times a year, a tessamarylin, ipamarylin with CJC 1295 cycle for growth hormone.
Those are the biggies. C-max and C-link intranasal. C-max is a little bit more of like a cognition, brain-derived neurotrophic factor booster, and then C-link is more of like an anxiolytic. So, kind of an up or downer. It's like my version of Valium Caffeine, yeah.
Brigham Buhler (1:29)
What he said.
Ben Greenfield (1:30)
Yeah.
Brigham Buhler (1:31)
Pretty much that protocol I agree with and I tell everyone the answer is not at the bottom of a peptide bottle, like diet, lifestyle, nutrition, living by the principles first. These are like additives that can help optimize your health, especially with our food sources and how stripped they are of the nutrients. The only compounds that I think I take that you didn't discuss is IGF LR3. I don't know if you've ever messed with that. Insulin Growth Factor LR3. A lot of people take growth hormone historically, but the reason they were taking growth hormone was in an effort to get all the therapeutic benefits that growth hormone gives you when it converts to IGF. If you were to use the peptide IGF, you get all the benefits of growth hormone, but with a much better safety profile that will not impact your natural growth hormone levels.
That's why I'm a huge fan of IGF.
Ben Greenfield (2:19)
Does it have a similar, pure HGH? You get a little bit of almost like a glucocorticoid response, where there's a surge in cortisol, your resting glucose tends to be higher, a lot of people don't sleep as well at night. Because it goes on a downstream pathway, do you skip out on a lot of that?
Brigham Buhler (2:37)
Yeah, you do skip out on a lot of that, but bigger than that is you're not impacting your natural growth levels.
So, you're still in your 40s, I'm in my 40s, 46 So I want to be cognizant of that. But anytime I come off, so I'll go on for four to six weeks, and then when I come off, I'll cycle on to CJC and some of the other things you discussed just to boost my natural growth hormone levels.
Dr. Gabrielle Lyon (2:57)
So I have the simplest protocol here, sounds like.
I will microdose GLP-1 once in a while for inflammation. I think there's going to be new emerging research. I was actually at the Protein Working Group Summit 3.0, and that is like the Oscars for nerds and protein scientists.
Brigham Buhler (3:17)
Sounds like it.
Dr. Gabrielle Lyon (3:18)
Invitation only, a hundred of the finest scientists that are doing protein research, and there were topics of discussion like, what are the challenges that we face? But more importantly, I sat with Arne Astrup, who discovered GLP-1's impact on appetite. So, he was essentially responsible for what we now have is this obesity, now not called obesity sarcopenic epidemic, GLP-1 use, which again, I am totally for GLP-1s, but that is my-
Chris Williamson (3:49)
Cool.
Ben Greenfield (3:50)
You said you're microdosing it for inflammation?
Dr. Gabrielle Lyon (3:52)
Yes, and there is going to be new emerging research that is going to have an impact on cancer, they believe.
That low dose GLP-1, we don't totally know. He believes it's through inflammation, and this is the guy who discovered GLP-1's effect on appetite.
Chris Williamson (4:09)
How do you know that it's not just a reduction in the turnover of food? We don't. We don't. So all of this could just be- Eating less cancer-causing food.
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