#440 GENETICS Based Supplements You Should AVOID - Dr Tyler Panzner artwork

#440 GENETICS Based Supplements You Should AVOID - Dr Tyler Panzner

Siim Land Podcast

February 15, 2025

00:00 Introduction 01:40 How Tyler Got Into Genetics 07:00 How Genes Affect Caffeine Metabolism 14:35 Creatine and Genetics 22:40 Citrulline and Arginine 27:35 Glycine 32:35 Histamine, Fermented Foods, Bone Broth 37:20 Food Sensitivities and Plant Chemicals 41:00 Methylation 44:05 Microplastics...

Speakers Tyler Panzner, Siim Land

TopicsHealth & Fitness

Tyler Panzner (0:00)

Again, I think anyone that's barking that like, this is good or bad for every human, they clearly don't know what they're talking about because we are all very different. I think that and vitamin D, I think those are the top two most wrongly demonized supplements. Does everyone need high doses? No, of course not. But the same exact thing that healed you is rarely what keeps you healthy.

Siim Land (0:20)

Tyler, welcome to the show.

Tyler Panzner (0:22)

Thank you so much for having me, my man.

Siim Land (0:24)

Yeah, I'm very excited to have you because you cover something that tends to go a little bit under the radar in health information, which is the bio-individuality and how your genes affect, how you respond to different foods and supplements and those kind of things, which many people kind of know already. But in the health space, there's always tends to be like this one size fits all solution to all the problems out there. But the reality is that it's a lot more nuanced and complex than that. So yeah, I'm excited to have a discussion with you about it.

Tyler Panzner (0:59)

Yeah, you know, it's one of those things that there's an overabundance of people, especially on social media now, right, that can say or regurgitate, you know, the information that you read on the supplement label, right, or on the bottle, or, you know, we know this supplement helps with inflammation, this or that, but what else is it doing in the body? Right? I'm sure you know this, you know, every supplement or nutrient has many mechanisms, and we really need to also make sure that not just that the mechanisms serve us, but not that some of those mechanisms don't also, you know, have deleterious or negative effects on our physiology.

Siim Land (1:40)

Yeah, maybe you can also talk a little bit about how you got into this and what's your like backstory, because it's quite interesting how you like, you know, stumbled upon this field yourself.

Tyler Panzner (1:52)

Yeah, absolutely. So, I always really loved science. I actually wanted to be the next crocodile hunter when I was a kid. So really loved the animals. Steve Irwin was, you know, my idol. Rest in peace. So when it came to biology, I always loved biology, but it was more. We'll call it the macro biology, right? More like animal biology. I think it was 11th grade. I took biology and we talked about cells and just so fascinating that it's like we have a whole city or a world inside of each one of our cells, all these organelles, all these proteins doing these things. So I did my undergrad at University of South Florida in molecular and cellular biology. Loved the molecular side, really got into supplements, biohacking was making my own pre-workout in my dorm room. And, you know, like selling that at the school gym and stuff, you know, and just how you can. Oh, I put, you know, this stimulant in there. I'm way more anxious than if I just take caffeine, you know, really interesting, all these little things, how I can make myself more calm if I want to be more calm based on what I put in my body or more energized. I was trying to figure out what to do after that. And ironically enough, I didn't want to work with people directly. I don't want to be a doctor, people yelling at me for, you know, drugs or this or that. And pharmacy, I didn't really want to be yelled at for, again, medications and stuff. And one of my professors mentioned pharmacology. And, you know, the questions I would ask, I think you do well in research. Looked up what pharmacology was. And I'm like, this is literally me. Ironically, I didn't realize what pharmacology was until end of undergrad. But knowing the why, I looked down at my coffee and I'm like, oh, so it doesn't magically wake me up. There's a molecule that blocks a receptor which blocks the tired signal. So that's why I'm awake. Right? So knowing the why there, I decided to do a PhD right out of undergrad in pharmacology. And I did some stem cell work, anxiety work, I ended up doing my thesis work on breast cancer, breast cancer metastasis. And I remember a period of poor health. You know, I've dealt with anxiety, brain fog, sleep issues.

And I got my 23andMe done. And this was probably seven, eight years ago. And I thought I was going to change my life, all these great insights. And back then, 23andMe was not what it is now. And it was like more likely to think cilantro tastes like soap, or more likely to have your pee smell weird when you eat asparagus. And I'm like, that's cool, but that's not really going to impact my health. So I looked in the raw data myself, figured out some of my mutations, and was able to do targeted supplementation. Doctors wanted to put me on medications for some of these things. And I changed my life within a matter of days, or a week or two. And that's when I decided I wanted to be in personalized medicine. So after I graduated, I worked at an oncology company doing next generation sequencing analysis for about a year and a half. Started doing what I do now, working with people one-on-one, started my business. And it's been a little over two years since I've been doing that full-time. Worked with over 700 people. And here we are now just trying to bridge the gap between not just conventional medicine and holistic medicine, but also really ways of awareness. I think genetics are very undervalued by how we analyze them clinically and the supplement pharmacology. I mean, you know this, it's like the Wild West out there. Thank God they have people like you or me that can help cut some of the noise. But there's a lot of BS out there.

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