#2421 - Derek, More Plates More Dates

Joe Rogan (0:03)

The Joe Rogan Experience. Trained by day, Joe Rogan Podcast by night, all day. Oh, well, Derek, tell me about your new drink. Look at this here, red gummy fish. I'm about to try it for the first time. And this is a nootropic?

Derek (0:20)

Yeah, so it's, I think on the first episode, maybe, that I did with you, robust, eh?

Joe Rogan (0:27)

That's good.

Derek (0:27)

Yeah.

Joe Rogan (0:28)

Oh, that's delicious. I mean, robust, you're saying it like potentially is a negative thing.

Derek (0:32)

Oh, both, flavor and...

Joe Rogan (0:33)

I think it's great.

Derek (0:34)

Oh, right on.

Joe Rogan (0:35)

Red gummy fish, it's fucking delicious. I drank the shit out of this.

Derek (0:39)

Oh, I'm glad you like it.

Joe Rogan (0:39)

Oh, a lot of stuff in here. What's in here?

Derek (0:41)

So, I think it was the first time I was on, you asked me about guerrilla mind and the nootropic formula that I used before podcasts and, you know, to get cognitively dialed. And at the time, it was a capital-based formula. And it still is, it still exists. But taking what we could to suspend in a liquid format and getting it into something that's more like publicly and widely accepted, that they would want to drink on a regular basis and it's something you could use daily, it's kind of what we did in this. So, we included essentially like a daily use version of the guerrilla mind formula, which includes the tyrosine precursor for dopamine as well as other neurotransmitters, catecholamines like adrenaline or adrenaline.

Also, alpha GPC, the most bioavailable form of choline that crosses the blood-brain barrier and is pretty efficacious and also just a good choline source in general which most people are deficient in as a nutrient and I think completely unaware that it's actually important to be supplementing with potentially. Pretty hard to get an adequate amount of choline but...

Joe Rogan (1:44)

Where does it come from in food?

Derek (1:45)

Liver is a good source, eggs and in general, it's just like the highly nutrition-dense foods that you would get it from. A lot of people aren't focusing on specifically either because of caloric density or it's like an animal-based like nose-to-tail thing or fill in the blank. It's not impossible to do it. A lot of people who focus on it could probably relatively easily but it's still one of the things you have to focus on actually kind of like maneuvering into your diet typically. So, in general, most people are at least maybe like 50% of the way that are at best and that's even among people who I would say are relatively balanced-diet individuals.

Joe Rogan (2:24)

Interesting.

Derek (2:25)

So, I'm sure you're familiar with cholinergics and their impact on cognition and whatnot. Caffeine, tried and true.

Joe Rogan (2:33)

How much you got in here?

Derek (2:34)

200 milligrams.

Joe Rogan (2:35)

Nice.

Derek (2:36)

Very difficult decision trying to come up with what is the amount you're going to stick with in perpetuity in this thing.

Joe Rogan (2:41)

Everyone's addicted now. It's a real issue with caffeine.

Derek (2:44)

So, it's like the fine line balance of not too much. Something that is still tolerable, sustainable, going to be widely accepted and widely impactful on a beneficial level, but not overdoing it, and 200 is kind of what we landed on. And then, uradine monophosphate, pretty unique ingredient. I haven't seen anybody ever include it in a drink, let alone even in supplements typically.

Joe Rogan (3:04)

What is it?

Derek (3:05)

So, it's also something that operates via the cholinergic system, but in a different way. Mainly, its utility is kind of enhancing your sensitivity to stimulants. So somebody who is otherwise desensitized from, like, heightened exposure to things that either desensitize them to caffeine or nicotine or things of this nature, even some like the ADHD medications. This can actually, at least the literature suggests strongly that it enhances dopamine neurotransmission potential, so like, almost restoring function and damaged dopamine producing neurons in the brain. So you can kind of get a heightened impact out of the same level of stimulants. So a caffeine dose that might otherwise be, you're used to it now, you start to feel it again more than you used to without having to increase your caffeine intake. Yeah, so it's a pretty cool ingredient. And it seems to have some neuroprotective properties potentially as well. And some interesting literature on like Alzheimer's and whatnot, but it's more like fringe and to be determined how impactful it is. And then on top of that, we have alethinine, probably familiar with its effects, stacked with caffeine, increases alpha waves, good for verbal fluency as well as just general attention, concentration, but keeping you a little bit more balanced and mellow while you have the heightened stimulatory activity from the caffeine and the other kind of like dopaminergic compounds. And then also saffron extract, which is a totally unique inclusion in my opinion, still don't really see it in nootropic formulas, let alone in drinks. And it's something that in literature is shown to be as efficacious as pharmaceutical SSRIs without inducing the same erectile dysfunction inducing effects of it and without causing the same anhedonia inducing effects, which is kind of like the muting of like pleasure in the brain.