#2278 - Chase Hughes

Chase Hughes (0:01)

Joe Rogan Podcast, check it out.

Joe Rogan (0:03)

The Joe Rogan Experience. Train by day, Joe Rogan Podcast by night, all day. We're debuting these mugs, my friend Turkey Merck on Instagram sent me these Cheshire Cat mugs. Isn't that badass?

Chase Hughes (0:22)

Yeah, that's really good.

Joe Rogan (0:24)

Thought it would be good for you, because we're talking about mind fucks. Cheshire Cat's a little bit of a mind fuck.

Chase Hughes (0:29)

In the simulation.

Joe Rogan (0:31)

Yeah, for sure. So you were just telling me that you had a brain disease, and you, what did you do to fix it?

Chase Hughes (0:42)

So I... What was it, first of all? It's temporal epilepsy with mesial temporal sclerosis.

Joe Rogan (0:50)

When did you develop this?

Chase Hughes (0:51)

We don't know, but I started having seizures, like, a few years ago, and everybody in my family knows I'm a neuroscientist. I'd say with a lowercase n, not a Ph.D. Neuroscientist, but...

Joe Rogan (1:03)

But you study neuroscience?

Chase Hughes (1:04)

Yeah. I had post-grad at Harvard and Duke, but they assumed, you know, Chase has studied all this stuff. He's going to know if he's having seizures, but these seizures come with amnesia. So I didn't remember that I was having any of them. And this was, like, three years ago. I had retired from the military and then started having these seizures. So then I found a neurologist, the drug that they gave me, the number one side effect was seizures from this pharmaceutical company. So I kind of looked around, and I found this guy is a functional medicine guy, and he got me on methylene blue to start off. And I know Mel Gibson was on here talking about it. And that instantly stopped everything. And some other stuff.

Joe Rogan (1:55)

That stuff was a fabric dye, right?

Chase Hughes (1:57)

Yeah, in 1890

Joe Rogan (1:59)

How weird.

Who the fuck drank it first? Who's that guy? Make blue jeans out of that? What do it taste like?

Chase Hughes (2:09)

Yeah.

Joe Rogan (2:10)

What if I drink it every day, if it affects my health?

Chase Hughes (2:12)

It tastes like chewing an ass.

Joe Rogan (2:14)

I'd take it.

Chase Hughes (2:15)

Okay.

Joe Rogan (2:16)

Yeah.

Chase Hughes (2:16)

I take it every day as well.

Joe Rogan (2:18)

Yeah, RFK Jr. told me about it.

Chase Hughes (2:19)

Yeah, man, it's fantastic. And so this guy's injecting, in 1890, injects these rats with it, and then does an autopsy on these things, and their brain, the brain stem, every single nerve is blue. So he discovered this methylene blue has an affinity for neuronal tissue. So he says, well, it's sucking into neurons. What's it doing? So we could talk about, if you want to, but how it's working and working in the body. So we started putting it in humans, and we found out it's an MAOI, which is...

Joe Rogan (2:52)

Monoamine Oxide Inhibitor.

Chase Hughes (2:54)

Yeah. Which helps with depression and anxiety and all kinds of life stress and stuff.

Joe Rogan (3:00)

Does it cause side effects if you're taking any drug that you shouldn't take with an MAOI?

Chase Hughes (3:06)

There are some studies that have been recalled that said you can't take it with SSRIs because you could develop serotonin syndrome. But they did recall the studies, as far as I'm aware. And it is so incredible that it acts as an electron donor to mitochondria, especially your neuronal mitochondria. So it helps you produce more ATP, and it helps you get rid of this stuff called reactive oxygen species. So you have an oxygen molecule, it should have two hydrogens on it, and like your body's job is to convert stuff into water so you can pee it out. So if you get an oxygen molecule, it's got four, five, one, it's a reactive oxygen, which we call free radicals.

So methylene logo is in there and balances a lot of those things out in your brain and your nervous system. So it is a miracle, and it's been proven for a hundred years. It's one of the most well-proven drugs out there.

Joe Rogan (4:03)

What's the side effects of it? Are there any?

Chase Hughes (4:06)

Not a bunch.

Joe Rogan (4:06)

I would imagine if you're taking an MAOI, there's wild shit going on there.

Chase Hughes (4:13)

Yeah, like if you mix it with anything that has metyramine in it, like aged cheeses, red wine, you're not supposed to mix it. If you're on a high dose though, but you're probably taking one milligram per kilogram, and you weigh probably 75 kilograms.