Special episode: Peter on exercise, fasting, nutrition, stem cells, geroprotective drugs, and more — promising interventions or just noise?

**Peter Attia** (0:11)
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Welcome to a special episode of The Drive. Today we celebrate our 300th episode. To celebrate this milestone, we're gonna do something a little different for this episode, but it's going to mirror the structure of a recent interview I did, which I thought was kind of interesting. For today's episode, we're going to cover a variety of topics, which you have all weighed in on, and I'm going to rank them into the following categories, proven, promising, fuzzy, noise and nonsense. Couple of months ago, some of you may recall, I put out a video on social media where I asked people to weigh in on the types of topics that they wanted to hear covered, and we got a lot of responses, literally thousands of responses. We've sorted those into different categories, and we're about to cover half of them here. Turns out the response was far in excess of what we predicted, and we'll have to finish this another time. But nevertheless, in this conversation, we're going to cover geroprotective drugs, including rapamycin, NAD and its precursors, metformin, resveratrol. We're going to talk about VO2 max, muscle mass, blood flow restriction, stem cells. And then we talk about nutrition, specifically questions you had around long-term fasting, sugar, sugar substitutes, and the role of red meat in cancer. So all of these topics have generally been covered in greater detail across the previous 300 episodes and or across our newsletter over the past 10 years. We will certainly point you back to areas where we go into great detail into these topics. But the goal here today is that if you're coming to these topics without any background, or you just want the TLDR, this is the place for you. So as such, if you want to learn more, of course, check out the show notes, both here and elsewhere. And I would just say, before we jump into this, I want to thank everybody for being a part of The Drive. Whether this is your first episode or your 300th, it is an absolute honor to be learning in front of you. And that's exactly how I feel about this. So without further delay, please enjoy this episode celebrating 300 episodes of The Drive and counting.

**SPEAKER_1** (3:14)
Peter, welcome to a special podcast. How are you doing?

**Peter Attia** (3:19)
Very good, thank you.

**SPEAKER_1** (3:20)
So today for this episode, we are actually celebrating 300 episodes. So I think the first question is, did you ever think we would get to episode 300 when we started this seven years ago, recording the first few?

**Peter Attia** (3:36)
Was it seven years ago or six years ago?

**SPEAKER_1** (3:38)
Well, it's launched in June 2018, but we were recording previous because the original episodes were you doing book research.

**Peter Attia** (3:48)
Right, yeah, that's right. So started having some of these discussions in 2017 I never really thought about it. To me, it was like binary, right? We started it as a 12-part series, and it was like either this is going to be uninteresting, unhelpful, useless, in which it dies, or it's going to be potentially interesting and valuable, and we'll keep doing it. But once we hit that binary spot where after three months we said, yeah, let's keep doing it, I never really thought of milestones in that way.

**SPEAKER_1** (4:14)
So what we like to do for every 100 episodes is to kind of just do a special episode, something a little different, release it to everybody.
Shot as an AMA, but just a little bit of a different style. And so when we're thinking of how we wanted to do this one, we thought of a recent interview you did, which was structured in a way we kind of liked, which was you giving your opinion on various drugs, supplements, behaviors, interventions, and putting them in the following categories, proven, promising, fuzzy, noise, nonsense.