AMA #76: Peter evaluates longevity drugs, aspirin for CVD, and strategies to improve muscle mass — proven, promising, fuzzy, noise, or nonsense?

**Peter Attia** (0:10)
Hey, everyone, welcome to a sneak peek, Ask Me Anything or AMA episode of the Drive podcast. I'm your host, Peter Attia. At the end of this short episode, I'll explain how you can access the AMA episodes in full, along with a ton of other membership benefits we've created. Or you can learn more now by going to peterattiamd.com/subscribe. So without further delay, here's today's sneak peek of the Ask Me Anything episode.
Welcome to Ask Me Anything AMA episode number 76 In today's AMA, we revisit the proving, promising, fuzzy, noise, nonsense scale and apply it to a variety of commonly inquired about and hot button topics. We start with a quick reset on what each bucket means and define them, of course. And then we walk through every topic where we're gonna land on. So the goal of this episode is that if you're coming to this topic without any previous background or you just want the TLDR, this is the place for you. We group the topics by the intended outcome. There are three categories today. Drugs for Giro protection, where we cover GLP-1 agonists, SGLT-2 inhibitors, methylene blue, and telomere lengthening supplements. Talk about low dose aspirin for CVD prevention. And then we look at interventions to improve muscle mass, talking specifically about protein, but also follistatin gene therapy. If you're a subscriber and want to watch the full video of this podcast, you can find it on the show notes page. And if you're not a subscriber, you can watch the sneak peek of this video on our YouTube page. So without further delay, I hope you enjoy AMA 76

**SPEAKER_2** (1:57)
All right, Peter, Attia, doctor, podcaster, author, speaker, bad chess player, how are you doing today?

**Peter Attia** (2:09)
Hey, hey, hey, hey, hey, hey, hey, you could say shepherd in there. You don't have to take sheep shots.

**SPEAKER_2** (2:16)
Shepherd of diabetic sheep, race car driver. Anything else missing?

**Peter Attia** (2:21)
Oh, that's good.

**SPEAKER_2** (2:23)
That's good. All right, I just didn't want to forget the diabetic sheep out there. That's true, that's true. How's the day going today?

**Peter Attia** (2:30)
Started out good, then took a little dip with the follow-up chess match, but there's a recurring theme here that I know you just love picking this scab.

**SPEAKER_2** (2:39)
Well, I just, sometimes you think about feats, like Tom Brady, right? Like what he went through.

**Peter Attia** (2:46)
Greatest of all time, right?

**SPEAKER_2** (2:47)
Yeah, people who come back from injuries. Demar Hamlin, like almost died, came back and played. I mean, like you getting second in a four-person in-house chess tournament with two children has to be up there, right?

**Peter Attia** (3:03)
Listen. We all started playing at the same time.

**SPEAKER_2** (3:09)
Pogacar just won the tour again, went through, two in a row, grueling. Not as mentally tough as what you went through, though, a month ago.

**Peter Attia** (3:19)
I would argue what I go through on the daily, trying to just make sure I don't get beat by an eight-year-old in chess, is at least on par mentally with some of the feats you're talking about.

**SPEAKER_2** (3:32)
We need to have Tom on the podcast, and you should ask him about it. Which one was harder? All those Super Bowls.

**Peter Attia** (3:38)
Is it harder to be down 28 to 3, having thrown a pick six in the Super Bowl, or succumbing to an eight-year-old's gambit, which is tougher?

**SPEAKER_2** (3:52)
To be fair, there is a real chance the eight-year-old might have talked more trash than what was going on in the Super Bowl, which says something. Yep. All right, so today is AMA, not about chess. It's gonna be a little different. So what we're gonna do is cover a variety of topics, looking at it through a certain lens, which is we are gonna take concepts and things that we've talked about before, some new things that we haven't talked about before, that we get asked about a lot. And instead of going super deep in them, we're gonna kind of summarize them into how you think about them. And we're gonna do it into five different buckets. And those buckets are proven, promising, fuzzy, noise, nonsense. People who have listened for a bit will remember this. We did this in episode 300 of the podcast, which was back in May 2024 So it's been a little bit, but people really liked it because it allowed us to cover a variety of topics. It allowed us to summarize them. And it allowed us to kind of look at them in an apples to apples comparison with what we know about them and how people should be thinking about it. So in today's episode, we are going to look at some geroprotective drugs like GLP-1s, things like Ozempic, SGLT-2 inhibitors, both of which we talked about before. We're going to look at Methylene Blue and Halomere lengthening supplements. Those are kind of newer. We're going to look at what we know about low dose aspirin and cardiovascular disease prevention. And then we're going to look at interventions that can help improve muscle mass, things like protein, folic acid and gene therapy, et cetera. Hopefully a good variety of things for people. Hopefully kind of a way to go through it, where people can kind of look, get clear, clean takeaways. With that said, anything you want to add before we get rolling?